The Secretory Clear Cell of the Eccrine Sweat Gland as the Probable Source of Excess Sweat Production in Hyperhidrosis

    August 2011 in “ Experimental Dermatology ”
    DL Bovell, Alison MacDonald, Birgit Meyer, A.D. Corbett, William M. Maclaren, S. Holmes, Mark Harker
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    TLDR Eccrine sweat gland's clear cells likely cause excessive sweating in hyperhidrosis.
    The document presents findings from two separate studies. The first study explored the effects of testosterone and epigallocatechin gallate (EGCG) on hair follicles in a B6CBAF1/j mouse model. It concluded that testosterone induces hair loss through apoptosis of hair follicles, while EGCG prevents this hair loss and promotes regrowth. The study suggests EGCG as a potential treatment for androgen-related hair loss, but acknowledges the limitations of the mouse model and calls for further in vitro research. The number of mice used in the study was not specified. The second study focused on hyperhidrosis and identified the eccrine gland's clear secretory epithelial cell as the probable source of excess sweat production in the condition. The study did not find evidence of apoeccrine gland involvement or gland hypertrophy in hyperhidrosis. The findings indicate that the eccrine clear cell, with its fluid secretion components, could be targeted for hyperhidrosis treatment. The study was supported by Unilever plc with no conflicts of interest reported.
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