Alfatradiol: What does a form of estrogen have to do with hairloss in men?Alfatradiol (17α-estradiol) is a prescription topical hormone, licensed for androgenetic alopecia in Germany but not FDA-approved. The controlled trial evidence is in women, where it produced stabilisation rather than regrowth and was outperformed by minoxidil; no comparable placebo-controlled trial in men appears to have been published.
Does hair strand thickness decrease in men with androgenic alopecia? Can finasteride help restore it?Androgenic alopecia thins hair strands by miniaturizing follicles. The pivotal finasteride trials (1,553 men, 1 mg/day, two years) report increased hair counts and improved assessed appearance, but they measured density, not the diameter of individual strands, so the effect on thickness itself is not established.
3 citations
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February 2022 in “Journal of Dermatological Science”
This study identified clinical features and genetic variants associated with early onset female pattern hairloss, highlighting decreased hair shaft density and specific SNPs related to androgenic features.
Hormonal treatments can help with hairloss, acne, and excess hair growth, but it takes 3-6 months to see results and patients should know the possible side effects.
This review discusses types of hairloss in elderly women, highlighting diagnostic challenges and treatment limitations, but does not present new research findings.
The conversation discusses using cyproterone temporarily to reverse hairloss, followed by finasteride to maintain regrowth. Concerns about cyproterone's side effects, such as lowering testosterone and potential health risks, are raised, with alternatives like spironolactone suggested for androgen-related issues.
The conversation discusses hairloss linked to BDNF-increasing nootropics like Semax and Lions Mane. Suggested topical treatments include capsaicin, beta-glucan, and ginseng to counteract TGF-B activation.
OP shares their experience with PCOS-relatedhairloss, highlighting that addressing vitamin D and ferritin deficiencies, managing hormones with spironolactone, and using gentle hair care products helped improve their condition. They advise against relying on "miracle" hair oils and emphasize the importance of medical evaluation and a combined approach to treatment.
High sugar diets may worsen hairloss by increasing 5α-reductase activity and androgen levels, especially in women with PCOS. A low sugar diet might reduce scalp DHT levels, similar to finasteride, but genetics also significantly influence hairloss.
The conversation is about using minoxidil for hairlossrelated to iron deficiency. The user experienced reduced hairloss after taking iron supplements and questions the need for minoxidil, which is typically used for hairloss from DHT.