Pharmacologic Interventions in Aging Hair

    April 2006 in “ Clinical Interventions in Aging
    Ralph M. Trüeb
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    TLDR Minoxidil and Finasteride are effective for male baldness; more research is needed for hair aging treatments.
    The 2006 document "Pharmacologic interventions in aging hair" discussed the effects of various drugs on hair aging and loss. Minoxidil and Finasteride were identified as the most effective treatments for male pattern baldness, with Minoxidil promoting hair growth and Finasteride inhibiting the hormone causing hair loss. The use of anti-androgens and estrogens for female pattern hair loss was also mentioned, but their effectiveness was less established. The paper also discussed the aging process of hair, including weathering of the hair shaft, decrease of melanocyte function, and decrease in hair production. Intrinsic factors like genetic and epigenetic mechanisms and extrinsic factors like UV radiation and air pollution were identified as affecting hair aging. The document also suggested that inflammation in hair follicles can lead to hair loss and that UV radiation can contribute to hair loss. The paper concluded that more research was needed to develop effective treatments for hair aging.
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      community Testosterone and hair loss seeming irrelevance

      in Research/Science  81 upvotes 1 year ago
      The conversation is about the role of testosterone in hair loss and the effectiveness of different treatments. The conclusion is that DHT is the main culprit for hair loss, and finasteride has been proven to work long-term in maintaining and regrowing hair. Testosterone may have a minor effect, but it is not the primary cause of hair loss.

      community Female, 30, PCOS diagnosis, MPB Norwood 2. Endo refuses to give anything other than Spironolactone. Feel like I’m at my wit’s end here.

      in Female  55 upvotes 1 year ago
      A 30-year-old female with PCOS and male pattern baldness is frustrated with her endocrinologist's recommendation of only Spironolactone and minoxidil, feeling that dutasteride, finasteride, and progesterone would be more effective. Other users suggest various online sources for treatments, warn against self-medicating due to potential risks, and recommend seeking a specialized endocrinologist or considering additional treatments like Inositol, Berberine, and dermaneedling.

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