Innate Type 2 Immunity Controls Hair Follicle Commensalism by Demodex Mites

    August 2022 in “ Immunity ”
    Roberto R. Ricardo-González, Maya E. Kotas, Claire E. O’Leary, Katelyn Singh, William Damsky, Chang Liao, Elizabeth Arouge, Iliana Tenvooren, Diana M. Marquez, Andrew Schroeder, Jarish N. Cohen, Marlys S. Fassett, Jinwoo Lee, Scott G. Daniel, Kyle Bittinger, Roberto Efraín Díaz, James S. Fraser, Niwa Ali, K. Mark Ansel, Matthew H. Spitzer, Hong-Erh Liang, Richard M. Locksley
    TLDR Type 2 immunity helps control mite growth in hair follicles, preventing damage.
    The study explores the role of innate type 2 immunity in regulating Demodex mite colonization in hair follicles, emphasizing the importance of group 2 innate lymphoid cells (ILC2s) and interleukin-13 (IL-13) in maintaining skin homeostasis. In type 2 immunodeficient mice, the absence of these immune components leads to increased mite proliferation, inflammation, and hair follicle exhaustion, resembling human rhinophyma. The research suggests that type 2 immunity, particularly through IL-13 and ILC2s, is crucial for preventing pathological mite overgrowth and maintaining hair follicle integrity, highlighting potential benefits of targeted screening and treatments for managing Demodex-related skin conditions.
    Discuss this study in the Community →

    Research cited in this study

    4 / 4 results

    Related Community Posts Join

    6 / 25 results

      community Just found out I am Vitamin D deficient

      in Treatment  58 upvotes 4 years ago
      A user found out they are vitamin D deficient and was prescribed high-dose vitamin D supplements, asking if others had similar experiences and if it improved their hair. Some shared improved mood and testosterone levels after treatment, while another combined vitamin D supplements with finasteride due to family history of baldness.

      community Will Pp405 be the Ozempic of bald Guys

      in Research/Science  102 upvotes 1 month ago
      PP405 is being discussed as a potential hair loss treatment, possibly more effective than minoxidil. There are concerns about its effectiveness and product contamination, but some users report early signs of hair regrowth.

      community Comprehensive Microneedling Guide

      in Microneedling  291 upvotes 3 years ago
      Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

      community TresslessGPT is available to ChatGPT Plus users

      in 📣 Announcement  107 upvotes 2 years ago
      The conversation introduces a specialized chatbot for ChatGPT Plus users that provides advice on hair loss treatments, drawing from research and community insights. It mentions treatments like RU58841, the "big 4" (likely minoxidil, finasteride, ketoconazole, and tretinoin), dutasteride mesotherapy, topical melatonin, microneedling, and rapamycin.

      community Quit vaping/smoking = 80% less loss

      in Research/Science  235 upvotes 1 year ago
      Quitting vaping significantly reduced hair loss for a user who was a heavy vaper and also taking finasteride. Some participants suggest nicotine's vasoconstrictive properties may worsen hair loss, while others share personal anecdotes of hair improvement after quitting smoking or vaping.

    Similar Research

    6 / 1000+ results