TLDR Type 2 immunity helps control mite growth in hair follicles, preventing damage.
The study explores the role of innate type 2 immunity in regulating Demodex mite colonization in hair follicles, emphasizing the importance of group 2 innate lymphoid cells (ILC2s) and interleukin-13 (IL-13) in maintaining skin homeostasis. In type 2 immunodeficient mice, the absence of these immune components leads to increased mite proliferation, inflammation, and hair follicle exhaustion, resembling human rhinophyma. The research suggests that type 2 immunity, particularly through IL-13 and ILC2s, is crucial for preventing pathological mite overgrowth and maintaining hair follicle integrity, highlighting potential benefits of targeted screening and treatments for managing Demodex-related skin conditions.
181 citations,
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April 2017 in “Cell” Different small areas within hair follicles send specific signals that control what type of cells stem cells become.
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June 2012 in “Nature Immunology” Hair follicles help attract immune cells to the skin during stress.
March 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” A specific immune response helps control mite populations on the skin, maintaining healthy hair follicles.
November 2023 in “Frontiers in cell and developmental biology” Hair aging is caused by stress, hormones, inflammation, and DNA damage affecting hair growth and color.
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