11 citations
,
September 2014 in “International Journal of Molecular Sciences” This study found that mycophenolate may stabilize β-catenin and counteract interferon-γ-induced catagen changes in human dermal papilla cells, which could promote hair growth.
9 citations
,
January 2014 in “Medical Hypotheses” This article discusses the hypothesis that mechanisms driving androgenic alopecia may reduce the risk and proliferation of prostate cancer by increasing prostaglandin D2 levels but presents no new clinical findings.
68 citations
,
November 2012 in “Journal of Investigative Dermatology” This study found that PGD2 inhibits hair follicle regeneration in mice through the Gpr44 receptor, suggesting that blocking PGD2 or Gpr44 may enhance skin regeneration after wounds.
205 citations
,
March 2012 in “Science Translational Medicine” PGD2 stops hair growth and is higher in bald men with AGA.
22 citations
,
March 2012 in “Molecular Medicine Reports” This study found that DHT treatment led to reduced cell growth, increased cell death, cell cycle arrest, ROS production, and senescence in normal human dermal papilla cells, potentially mediated by altered miRNA expression.
19 citations
,
December 2011 in “PubMed” This study found that women with androgenetic alopecia showing a positive immunoreactant profile responded well to combined therapy with minocycline, topical steroids, and red light, indicating an immunologically driven trigger.
122 citations
,
November 2010 in “Journal of Dermatological Science” This study found that increased expression of type II 5α-reductase, androgen receptors, and Hic-5/ARA55 in dermal papilla cells upregulates androgen sensitivity, playing a key role in androgenetic alopecia pathogenesis.
58 citations
,
January 2006 in “Skin Pharmacology and Physiology” This study found that testosterone and 5α-dihydrotestosterone induced apoptosis in dermal papilla cells from nonbalding scalp regions, suggesting a high androgen stimulus can trigger cell death related to androgenetic alopecia.
41 citations
,
September 2003 in “Journal of Investigative Dermatology” This study suggests that the COX-2 enzyme plays a role in hair follicle biology, as transgenic overexpression in mice induced hair follicle cycling disturbances and alopecia, which was mitigated by COX-2 inhibition.
139 citations
,
June 2003 in “Journal of Investigative Dermatology Symposium Proceedings” This article reviews androgenetic alopecia in women, highlighting diagnosis criteria and noting that topical minoxidil is currently the only proven treatment for hair growth; it reports no clinical trial findings.
165 citations
,
December 2002 in “Molecular and Cellular Endocrinology” This study found that finasteride improves scalp hair growth in men with male pattern hair loss by reducing scalp dihydrotestosterone levels, but it did not benefit postmenopausal women with female pattern hair loss.
23 citations
,
August 2001 in “PubMed” In this study, finasteride treatment in men with androgenetic alopecia reduced the expression of caspases in hair follicles to levels similar to those in men with normal scalps.
131 citations
,
August 2000 in “International Journal of Dermatology” Inflammation may be linked to hair loss, and targeting specific enzymes could help treat it.
98 citations
,
November 1999 in “Dermatology Online Journal” This review discusses the effects of IGF-1 on hair follicle cell proliferation and differentiation, highlighting its roles in paracrine signaling, apoptosis prevention, and hair growth, but reports no new clinical results.
140 citations
,
December 1998 in “Journal of Investigative Dermatology” Apoptosis in hair follicles varies by growth phase, with TGF-β possibly starting the catagen phase.
179 citations
,
September 1998 in “BMJ” This article reviews the pathogenesis, genetic basis, and recent treatment breakthroughs for androgenetic alopecia but reports no new clinical findings.
19 citations
,
March 1996 in “British Journal of Dermatology” This study found that dermal papilla cells from balding follicles exhibit distinct growth characteristics compared to non-balding cells, suggesting their potential as a model for understanding androgenetic alopecia.
30 citations
,
March 1996 in “British Journal of Dermatology”
