Prostaglandin D2-Mediated DP2 and AKT Signal Regulate the Activation of Androgen Receptors in Human Dermal Papilla Cells

    February 2018 in “ International Journal of Molecular Sciences ”
    Kwan Jeong, Jin‐Woo Jung, Jung Eun Kim, Hoon Kang
    Studysummary This study found that prostaglandin D2 promotes androgen receptor and AKT signaling in human dermal papilla cells through the DP2 receptor, potentially contributing to androgenetic alopecia.
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    Research cited in this study 18

    1. Mycophenolate Antagonizes IFN-γ-Induced Catagen-Like Changes via β-Catenin Activation in Human Dermal Papilla Cells and Hair Follicles International Journal of Molecular Sciences · 2014
    2. Increased DHT Levels in Androgenic Alopecia Selected to Protect Men from Prostate Cancer Medical Hypotheses · 2014
    3. Prostaglandin D2 Inhibits Wound-Induced Hair Follicle Neogenesis Through the Receptor Gpr44 Journal of Investigative Dermatology · 2012
    4. Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia Science Translational Medicine · 2012
    5. Analysis of the MicroRNA Expression Profile of Normal Human Dermal Papilla Cells Treated with 5α-Dihydrotestosterone Molecular Medicine Reports · 2012
    6. The Role of Inflammation and Immunity in the Pathogenesis of Androgenetic Alopecia PubMed · 2011
    7. Molecular Basis of Androgenetic Alopecia: From Androgen to Paracrine Mediators Through Dermal Papilla Journal of Dermatological Science · 2010
    8. Effect of 5α-Dihydrotestosterone and Testosterone on Apoptosis in Human Dermal Papilla Cells Skin Pharmacology and Physiology · 2006
    9. Expression of Cyclooxygenase Isozymes During Morphogenesis and Cycling of Pelage Hair Follicles in Mouse Skin: Precocious Onset of the First Catagen Phase and Alopecia Upon Cyclooxygenase-2 Overexpression Journal of Investigative Dermatology · 2003
    10. Androgenetic Alopecia in Women Journal of Investigative Dermatology Symposium Proceedings · 2003
    11. Androgens and Alopecia Molecular and Cellular Endocrinology · 2002
    12. Androgen Responsive Genes as They Affect Hair Growth PubMed · 2001
    13. Androgenetic Alopecia and Microinflammation International Journal of Dermatology · 2000
    14. Insulin-Like Growth Factor 1 and Hair Growth Dermatology Online Journal · 1999
    15. Analysis of Apoptotic Cell Death in Human Hair Follicles In Vivo and In Vitro Journal of Investigative Dermatology · 1998
    16. Fortnightly Review: Male Pattern Androgenetic Alopecia BMJ · 1998
    17. A Comparison of the Culture and Growth of Dermal Papilla Cells from Hair Follicles from Non-Balding and Balding (Androgenetic Alopecia) Scalp British Journal of Dermatology · 1996
    18. A Comparison of the Culture and Growth of Dermal Papilla Cells from Hair Follicles from Non-Balding and Balding (Androgenetic Alopecia) Scalp British Journal of Dermatology · 1996

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    1. Prostaglandin D2-Mediated DP2 and AKT Signal Regulate the Activation of Androgen Receptors in Human Dermal Papilla Cells International Journal of Molecular Sciences · 2018