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    GlossaryIn Vivo Studies (in vivo experiment)

    experiments conducted within living organisms

    In vivo studies refer to experiments conducted within a living organism, such as a human, animal, or plant. These studies are crucial for understanding biological processes in their natural context, allowing researchers to observe the effects of treatments, drugs, or genetic modifications in a complex, real-life environment.

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      community P-1075: a BETTER version of Minoxidil

      in Research/Science 2 weeks ago
      P-1075 is a more potent hair growth agent than Minoxidil, but it poses significant heart risks, making it unsafe for use. Despite promising results in macaques, concerns about its cardiotoxicity in rats have halted its development.

      community Minoxidil is a 5ar inhibitor according to research

      in Research/Science  147 upvotes 3 weeks ago
      Minoxidil may inhibit androgen receptors and affect hormonal pathways, potentially explaining its effectiveness in treating androgenetic alopecia (AGA). Users discuss its varying effectiveness on scalp versus facial hair and note fewer side effects with topical use compared to oral.

      community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

      in Research/Science  737 upvotes 3 years ago
      A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.
      PP405 Identity Research

      community PP405 Identity Research

      in Research  292 upvotes 2 months ago
      PP405 is a potential hair loss treatment that inhibits mitochondrial pyruvate carriers, increasing lactate dehydrogenase activity and stimulating hair follicle stem cells. In a phase 1 trial, 31% of participants showed over 20% hair density increase with PP405 treatment.