TLDR New lipid nanoparticles show promise for delivering hair loss treatments but need improvement for better skin penetration.
The document from March 1, 2014, presents a study on the development of nanostructured lipid carriers (NLCs) for delivering minoxidil and finasteride for alopecia treatment. The NLCs were characterized by their size, surface charge, and morphology, and were found to have a mean size of around 200 nm and a stable zeta potential of about -30 mV, indicating good physical stability. Finasteride showed high loading efficiency (70-90%), while minoxidil was less efficient (<30%). In vitro release studies indicated a prolonged release for minoxidil, but finasteride did not release significantly within 24 hours. Penetration studies through pig ear skin showed low penetration levels for both drugs. The study concluded that the NLCs have potential as a delivery system for alopecia treatment, but further research is needed to improve skin penetration. The number of participants or samples was not specified as the study focused on in vitro experiments.
26 citations,
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May 2022 in “Asian Journal of Pharmaceutical Sciences” New hair follicle-targeting treatments show promise for hair disorders but need more research on safety and effectiveness.
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August 2018 in “Therapeutic Delivery” Nanotechnology could make hair loss treatments more effective and reduce side effects, but more research is needed before it's available.
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February 2022 in “Acta Biomaterialia” Nanomaterials can improve hair care products and treatments, including hair loss and alopecia, by enhancing stability and safety, and allowing controlled release of compounds, but their safety in cosmetics needs more understanding.
July 2024 in “ADMET & DMPK” Surface-modified nanostructured lipid carriers can improve hair growth treatments.
89 citations,
November 2014 in “International Journal of Nanomedicine” Using nanostructured lipid carriers to deliver spironolactone could improve treatment for hair loss.
