Solid Lipid Nanoparticles Suspension Versus Commercial Solutions for Dermal Delivery of Minoxidil

June 2011 in “ International Journal of Pharmaceutics ”

Karine Padois, Céline Cantiéni, Valérie Bertholle, Claire Bardel, Fabrice Pirot, Françoise Falson

solid lipid nanoparticles SLN minoxidil dermal delivery androgenic alopecia skin penetration non-corrosive commercial solutions Rogaine

TLDR SLN suspensions work as well as commercial solutions for minoxidil delivery, but are non-corrosive, making them a promising alternative.

This study compares the effectiveness of solid lipid nanoparticles (SLN) suspensions to commercial solutions for dermal delivery of minoxidil, a drug used to treat hair loss. The SLN suspensions were found to be as efficient as commercial solutions for skin penetration and were non-corrosive, while commercial solutions presented a corrosive potential. The study suggests that SLN suspensions could be a promising alternative for topical treatment of androgenic alopecia with minoxidil, as it could increase patient compliance due to its non-corrosive nature.

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Research cited in this study

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research Selective Follicular Targeting by Modification of the Particle Sizes

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research Liposomes And Niosomes As Potential Carriers For Dermal Delivery Of Minoxidil

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Liposomes better deliver minoxidil for hair loss treatment than niosomes.

research Minoxidil: Mechanisms of Action on Hair Growth

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research Treatments for Androgenetic Alopecia and Alopecia Areata

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research Penetration of Minoxidil from Ethanol/Propylene Glycol Solutions: Effect of Application Volume and Occlusion

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More ethanol increases minoxidil delivery, but too much lowers efficiency.

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research Solid Lipid Nanoparticles Suspension Versus Commercial Solutions for Dermal Delivery of Minoxidil

26 citations , June 2011 in “International Journal of Pharmaceutics”

SLN suspensions work as well as commercial solutions for minoxidil delivery, but are non-corrosive, making them a promising alternative.