Solid Lipid Nanoparticles Suspension Versus Commercial Solutions for Dermal Delivery of Minoxidil

June 2011 in “ International Journal of Pharmaceutics ”

Karine Padois, Céline Cantiéni, Valérie Bertholle, Claire Bardel, Fabrice Pirot, Françoise Falson

solid lipid nanoparticles SLN minoxidil dermal delivery androgenic alopecia skin penetration non-corrosive commercial solutions Rogaine

Studysummary This study found that solid lipid nanoparticles with minoxidil were as effective as commercial solutions for skin penetration and were non-corrosive, indicating potential for hair loss treatment. Our plain-language summary of this paper — not a Tressless recommendation.

This study compares the effectiveness of solid lipid nanoparticles (SLN) suspensions to commercial solutions for dermal delivery of minoxidil, a drug used to treat hair loss. The SLN suspensions were found to be as efficient as commercial solutions for skin penetration and were non-corrosive, while commercial solutions presented a corrosive potential. The study suggests that SLN suspensions could be a promising alternative for topical treatment of androgenic alopecia with minoxidil, as it could increase patient compliance due to its non-corrosive nature.

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