Search

for
Search:

Research

5 / 1000+ results

Lipid Nanoparticles for Topical and Transdermal Application for Alopecia Treatment: Development, Physicochemical Characterization, and In Vitro Release and Penetration Studies

research Lipid nanoparticles for topical and transdermal application for alopecia treatment: development, physicochemical characterization, and in vitro release and penetration studies

28 citations , March 2014 in “International Journal of Nanomedicine”

This study developed lipid nanoparticles for delivering minoxidil and finasteride to the dermis and hair follicles, showing stability and a desired prolonged release, though with low skin penetration levels.

research Morphological Studies of Penetration Pathways via Stratum corneum and Hair Follicles using Nano-sized Iron Oxide

1 citations , July 2017 in “Microscopy and Microanalysis”

In this study using C57BL/6 mice, researchers found that iron oxide nanoparticles permeated skin primarily through hair follicles and sebocytes, with absorption increasing over time.

research Studies on the efficacy of methyl esters of n-alkyl fatty acids as penetration enhancers

3 citations , September 1989 in “Journal of Investigative Dermatology”

This study found that methyl nonanoate and methyl caprate significantly enhanced the skin penetration of minoxidil compared to solutions with other common enhancers like Azone, DMSO, or DEET.

research Optical Studies of Nanodiamond-Tissue Interaction: Skin Penetration and Localization

14 citations , November 2019 in “Materials”

This study found that nanodiamonds of various sizes can penetrate different layers of murine skin in vitro, reaching hair follicle niches, and may be suitable for multimodal imaging applications.

research 144 Evaluation of contamination and quantification of drug penetrations studies using Quantitative Mass Spectrometry Imaging

September 2017 in “Journal of Investigative Dermatology”

QMSI effectively maps and quantifies drug distribution in skin tissues.

View more "penetration studies" in research →

Community Join

5 / 198 results

community Be careful about using non-PG based alternatives of Minoxidil (mathematically speaking, haven’t seen much practical studies)

in Research/Science 7 upvotes 1 month ago

Minoxidil formulations often use propylene glycol (PG) for stability and effectiveness, but PG-free alternatives like foams and PEG-based solutions can also be effective with less irritation. Concerns exist about the quality of PG-free minoxidil from lesser-known brands, especially from India, due to potential manufacturing issues.

community Has Anyone Heard About Ethossomal Finasteride? 6x Finasteride Delivery in Hair Folicule?

36 upvotes 3 years ago

A user is considering switching from oral to topical finasteride to reduce systemic DHT impact and is exploring ethossomal finasteride for better skin penetration and potential hair regrowth. They found ethossomal finasteride in Brazil and are seeking opinions on its effectiveness compared to other topical delivery methods.

community Nanoxidil Is Probably Better Than Minoxidil. Big Pharma Is Why You’ve Never Heard Of It.

5 months ago

Nanoxidil may be more effective than Minoxidil for hair loss due to better follicle penetration, but it lacks widespread recognition and research because it's owned by a small company and classified as a cosmetic. The pharmaceutical system favors Minoxidil due to its established market presence and profitability, leaving Nanoxidil largely unstudied and unknown.

community Topical dutasteride significantly outperforms oral finasteride

in Research/Science 65 upvotes 11 months ago

Topical dutasteride 0.05% is reported to outperform oral finasteride with minimal side effects, but concerns about study bias exist due to company funding. Some users report mixed results with topical dutasteride, noting issues with skin penetration and systemic absorption.

community How is it possible for someone to be a non responder to ORAL minoxidil?

in Minoxidil 66 upvotes 2 years ago

Some individuals do not respond to oral minoxidil for hair loss, despite it generally working by improving blood flow to hair follicles. Factors like metabolism, drug interactions, and individual variations in the drug's activation may influence its effectiveness.

View more "penetration studies" in community →