Novel and Established Potassium Channel Openers Stimulate Hair Growth In Vitro: Implications for Their Modes of Action in Hair Follicles

    March 2005 in “ Journal of Investigative Dermatology ”
    G C Davies, M. Julie Thornton, Tracey J. Jenner … Valerie A. Randall
    Studysummary In this in vitro study, minoxidil, diazoxide, and the novel compound NNC 55-0118 increased hair follicle growth, supporting deer follicles as a viable bioassay for ATP-sensitive potassium channel modulators.
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    Research cited in this study 32

    1. Biphasic Effects of Minoxidil on the Proliferation and Differentiation of Normal Human Keratinocytes Skin Pharmacology and Physiology · 2009
    2. Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
    3. Minoxidil Opens Mitochondrial KATP Channels and Confers Cardioprotection British Journal of Pharmacology · 2004
    4. Animal and In Vitro Models for the Study of Hair Follicles Journal of Investigative Dermatology Symposium Proceedings · 2003
    5. Hypertrichosis in Females Applying Minoxidil Topical Solution and in Normal Controls Journal of The European Academy of Dermatology and Venereology · 2003
    6. A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 2002
    7. Minoxidil-Induced Hair Growth Is Mediated by Adenosine in Cultured Dermal Papilla Cells: Possible Involvement of Sulfonylurea Receptor 2B as a Target of Minoxidil Journal of Investigative Dermatology · 2001
    8. Changes in Hair Weight and Hair Count in Men with Androgenetic Alopecia After Application of 5% and 2% Topical Minoxidil, Placebo, or No Treatment Journal of The American Academy of Dermatology · 1999
    9. Hair Follicle Elongation in Organ Culture of Skin from Newborn and Adult Mice Journal of Dermatological Science · 1998
    10. Minoxidil Upregulates the Expression of Vascular Endothelial Growth Factor in Human Hair Dermal Papilla Cells British Journal of Dermatology · 1998
    11. Sulfation of Minoxidil by Multiple Human Cytosolic Sulfotransferases Chemico-Biological Interactions · 1998
    12. Whole Hair Follicle Culture Dermatologic clinics · 1996
    13. In the Absence of Streptomycin, Minoxidil Potentiates the Mitogenic Effects of Fetal Calf Serum, Insulin-Like Growth Factor 1, and Platelet-Derived Growth Factor on NIH 3T3 Fibroblasts in a K+ Channel-Dependent Fashion Journal of Investigative Dermatology · 1996
    14. Effect of Minoxidil Sulfate and Pinacidil on Single Potassium Channel Current in Cultured Human Outer Root Sheath Cells and Dermal Papilla Cells Journal of Dermatological Science · 1994
    15. Potassium Channel Conductance as a Control Mechanism in Hair Follicles Journal of Investigative Dermatology · 1993
    16. Enhanced In Vitro Hair Growth at the Air-Liquid Interface: Minoxidil Preserves the Root Sheath in Cultured Whisker Follicles In Vitro Cellular & Developmental Biology - Animal · 1993
    17. Organ Culture of Human Hair Follicles in Serum-Free Medium Archives of Dermatological Research · 1993
    18. Potassium Channel Openers Stimulate DNA Synthesis in Mouse Epidermal Keratinocyte and Whole Hair Follicle Cultures Skin Pharmacology and Physiology · 1993
    19. Potassium Channel Conductance: A Mechanism Affecting Hair Growth Both In Vitro and In Vivo Journal of Investigative Dermatology · 1992
    20. Localization of Minoxidil Sulfotransferase in Rat Liver and the Outer Root Sheath of Anagen Pelage and Vibrissa Follicles Journal of Investigative Dermatology · 1991
    21. Human Hair Growth In Vitro Journal of Cell Science · 1990
    22. Minoxidil Sulfate Is the Active Metabolite That Stimulates Hair Follicles Journal of Investigative Dermatology · 1990
    23. Minoxidil Stimulates Mouse Vibrissae Follicles in Organ Culture Journal of Investigative Dermatology · 1989
    24. The History of the Development of Minoxidil Clinics in Dermatology · 1988
    25. Nongenotoxicity of Minoxidil in Murine Hair Follicles as Determined by the Nuclear Aberration Assay Toxicology and Applied Pharmacology · 1988
    26. Alterations in Scalp Blood Flow After the Epicutaneous Application of 3% Minoxidil and 0.1% Hexyl Nicotinate in Alopecia British Journal of Dermatology · 1987
    27. Topical Minoxidil in Male Pattern Baldness: Effects of Discontinuation of Treatment Journal of The American Academy of Dermatology · 1987
    28. Action of Topical Minoxidil in the Bald Stump-Tailed Macaque Journal of The American Academy of Dermatology · 1987
    29. Topical Minoxidil in Early Male Pattern Baldness Journal of The American Academy of Dermatology · 1985
    30. Minoxidil Stimulates Cutaneous Blood Flow in Human Balding Scalps: Pharmacodynamics Measured by Laser Doppler Velocimetry and Photopulse Plethysmography Journal of Investigative Dermatology · 1984
    31. Sulfation of Minoxidil by Liver Sulfotransferase Biochemical Pharmacology · 1982
    32. Hypertrichosis Due to Minoxidil British Journal of Dermatology · 1979

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