Nongenotoxicity of Minoxidil in Murine Hair Follicles as Determined by the Nuclear Aberration Assay

    January 1988 in “ Toxicology and Applied Pharmacology ”
    R. N. Schop, Mark T. Goldberg
    TLDR Minoxidil promotes hair growth without causing DNA damage.
    The study titled "Nongenotoxicity of minoxidil in murine hair follicles as determined by the nuclear aberration assay" from 1988 investigated the effects of minoxidil on hair growth and its potential genotoxicity. It was found that minoxidil did not increase the frequency of micronuclei in the bone marrow of mice, suggesting it did not cause DNA damage in this context. This finding supported previous research by Schop and Goldberg in 1988, which also indicated a lack of genotoxic effects. Additionally, minoxidil was shown to stimulate hair growth, as evidenced by increased follicular DNA synthesis and higher mitotic activity in hair follicles, both in vitro and in vivo. These results highlighted minoxidil's role as a potassium channel opener that promotes hair growth without causing genetic damage.
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