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Glossary Glibenclamide

oral diabetes medication that stimulates insulin release from the pancreas

Glibenclamide, also known as Glyburide, is an oral medication used to manage type 2 diabetes. It belongs to a class of drugs called sulfonylureas, which work by stimulating the pancreas to release more insulin, thereby helping to lower blood sugar levels.

Research

5 / 110 results

research Glibenclamide inhibits cell growth by inducing G0/G1 arrest in the human breast cancer cell line MDA-MB-231

68 citations , January 2013 in “BMC Pharmacology and Toxicology”

This study found that glibenclamide exhibited a cytostatic effect on MDA-MB-231 breast cancer cells, potentially mediated through K ATP channels, and enhanced the antiproliferative impact of doxorubicin.

research Glibenclamide reverses cromakalim-induced anti-ischemic effect in conscious rabbits

1 citations , May 1992 in “Pharmacological Research”

research Potassium channel openers: pharmacological and clinical aspects

119 citations , October 1992 in “Fundamental & Clinical Pharmacology”

This review discusses the pharmacological properties and therapeutic potential of K+ channel opening compounds, noting their prospective use in treating cardiovascular and respiratory conditions, but reports no new results.

research Novel and Established Potassium Channel Openers Stimulate Hair Growth In Vitro: Implications for their Modes of Action in Hair Follicles

35 citations , March 2005 in “Journal of Investigative Dermatology”

In this in vitro study, minoxidil, diazoxide, and the novel compound NNC 55-0118 increased hair follicle growth, supporting deer follicles as a viable bioassay for ATP-sensitive potassium channel modulators.

research Pharmacological evidence for the involvement of adenosine triphosphate sensitive potassium channels in chloroquine-induced itch in mice

9 citations , June 2017 in “Pharmacological Reports”

This study found that ATP-sensitive potassium channels may play a role in chloroquine-induced itching in mice, as channel openers reduced scratching behavior while a blocker reversed these effects.

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