Minoxidil Opens Mitochondrial KATP Channels and Confers Cardioprotection

January 2004 in “ British Journal of Pharmacology ”

Toshiaki Sato, Yulong Li, Tomoaki Saito, Haruaki Nakaya

minoxidil mitochondrial KATP channels sarcKATP channels ischemia/reperfusion ventricular myocytes Rogaine

TLDR Minoxidil protects heart and improves recovery.

The study found that minoxidil, a drug used for hair growth, can activate mitochondrial KATP channels in the heart, which can protect the heart from damage and improve recovery after ischemia/reperfusion. Minoxidil was found to be more potent in opening mitoKATP channels than sarcKATP channels in guinea-pig ventricular myocytes. The study suggests that minoxidil has potential as a cardioprotective agent, but its clinical utility may be limited by significant side effects.

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