Minoxidil Opens Mitochondrial KATP Channels and Confers Cardioprotection

January 2004 in “ British Journal of Pharmacology ”

Toshiaki Sato, Yulong Li, Tomoaki Saito, Haruaki Nakaya

minoxidil mitochondrial KATP channels sarcKATP channels ischemia/reperfusion ventricular myocytes Rogaine

TLDR Minoxidil protects heart and improves recovery.

The study found that minoxidil, a drug used for hair growth, can activate mitochondrial KATP channels in the heart, which can protect the heart from damage and improve recovery after ischemia/reperfusion. Minoxidil was found to be more potent in opening mitoKATP channels than sarcKATP channels in guinea-pig ventricular myocytes. The study suggests that minoxidil has potential as a cardioprotective agent, but its clinical utility may be limited by significant side effects.

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Research cited in this study

3 / 3 results

research The Therapeutic Use of Topical Minoxidil

33 citations, April 1990 in “Dermatologic Clinics”

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47 citations, October 1989 in “Circulation Research”

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research Minoxidil: A Review of Its Pharmacological Properties and Therapeutic Use

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research Minoxidil Opens Mitochondrial KATP Channels and Confers Cardioprotection

28 citations, January 2004 in “British Journal of Pharmacology”

Minoxidil protects heart and improves recovery.