Minoxidil Opens Mitochondrial KATP Channels and Confers Cardioprotection

January 2004 in “ British Journal of Pharmacology ”

Toshiaki Sato, Yulong Li, Tomoaki Saito, Haruaki Nakaya

minoxidil mitochondrial KATP channels sarcKATP channels ischemia/reperfusion ventricular myocytes Rogaine

TLDR Minoxidil protects heart and improves recovery.

The study found that minoxidil, a drug used for hair growth, can activate mitochondrial KATP channels in the heart, which can protect the heart from damage and improve recovery after ischemia/reperfusion. Minoxidil was found to be more potent in opening mitoKATP channels than sarcKATP channels in guinea-pig ventricular myocytes. The study suggests that minoxidil has potential as a cardioprotective agent, but its clinical utility may be limited by significant side effects.

View this study on onlinelibrary.wiley.com →

Discuss this study in the Community →

Research cited in this study

3 / 3 results

research The Therapeutic Use of Topical Minoxidil

33 citations, April 1990 in “Dermatologic Clinics”

Minoxidil effectively treats hair loss, with better results in women.

research Electrophysiological Mechanisms of Minoxidil Sulfate-Induced Vasodilation of Rabbit Portal Vein

47 citations, October 1989 in “Circulation Research”

The study explains how minoxidil sulfate causes vasodilation in rabbits by opening potassium channels and inhibiting calcium channels.

research Minoxidil: A Review of Its Pharmacological Properties and Therapeutic Use

96 citations, October 1981 in “Drugs”

Minoxidil effectively treats severe hypertension but may cause side effects, so careful monitoring is needed.

Related Community Posts Join

6 / 1000+ results

Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

in Research 413 upvotes 2 months ago

Treating androgenic alopecia with minoxidil, finasteride, and antiandrogens, alongside exercise, cryotherapy, and natural substances to stimulate cold receptors for better hair growth. The method focuses on enhancing treatment effectiveness by considering environmental and behavioral factors and the role of cold receptors and muscle stress.

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens.

in Research/Science 2 upvotes 2 months ago

A method for treating androgenic alopecia using minoxidil, antiandrogens, exercise, and cold exposure to promote hair growth. Environmental factors and lifestyle changes, like diet and exercise, can improve treatment effectiveness.

community Countering oral minoxidil side effects by taking collagen supplements?

in Minoxidil 16 upvotes 8 months ago

Oral minoxidil may deplete collagen, potentially causing skin aging. Users discuss whether taking collagen supplements can counteract this effect.

community A meta analysis of 18 popular hair loss treatments. An 2022 guide on efficacy. From finasteride and minoxidil to caffeine shampoo, saw palmetto and biotin. 96 Scientific References included.

in Research/Science 104 upvotes 2 years ago

Most hair loss treatments are ineffective; only finasteride, dutasteride, and minoxidil show effectiveness.

community A science based addition to your hair loss routine

in Research/Science 23 upvotes 7 months ago

Blocking the Mitochondrial pyruvate carrier and using aldose reductase inhibitors like Indian gooseberry and berberine may help with hair growth. Magnesium can also be added to increase NADPH.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 862 upvotes 3 months ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

Related Research

1 / 1 results

research Minoxidil Opens Mitochondrial KATP Channels and Confers Cardioprotection

28 citations, January 2004 in “British Journal of Pharmacology”

Minoxidil protects heart and improves recovery.