Electrophysiological Mechanisms of Minoxidil Sulfate-Induced Vasodilation of Rabbit Portal Vein

October 1989 in “ Circulation Research ”

N. Leblanc, Dixon W. Wilde, Kathleen D. Keef, Joseph R. Hume

minoxidil sulfate vasodilation smooth muscle cells ATP-sensitive potassium channels voltage-dependent calcium channels hypertension hair loss Rogaine

TLDR The study explains how minoxidil sulfate causes vasodilation in rabbits by opening potassium channels and inhibiting calcium channels.

The study explores the mechanisms behind how minoxidil sulfate causes vasodilation in rabbit portal vein. It was found that it works by hyperpolarizing smooth muscle cells through the opening of ATP-sensitive potassium channels and inhibition of voltage-dependent calcium channels. This provides insight into the molecular mechanisms behind the vasodilation effects of minoxidil sulfate, which is used to treat hypertension and hair loss.