102 citations
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February 2008 in “The FASEB Journal” This study found that human hair follicles express ATP-sensitive potassium channels, suggesting that minoxidil acts on these channels and that drugs targeting them may treat hair disorders.
35 citations
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March 2005 in “Journal of Investigative Dermatology” In this in vitro study, minoxidil, diazoxide, and the novel compound NNC 55-0118 increased hair follicle growth, supporting deer follicles as a viable bioassay for ATP-sensitive potassium channel modulators.
18 citations
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November 2017 in “JoLS Journal of Life Sciences” This study investigates the effects of Tenebrio molitor as a novel biomaterial for preventing alopecia and promoting hair growth, but reports no conclusive results.
In this study, deer hair follicles were shown to be an effective in vitro bioassay model, demonstrating that K(ATP) channel modulators directly influence hair follicle growth through specific channel types.
3 citations
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September 1989 in “Journal of Investigative Dermatology” This study found that methyl nonanoate and methyl caprate significantly enhanced the skin penetration of minoxidil compared to solutions with other common enhancers like Azone, DMSO, or DEET.