69 citations,
January 2002 in “Journal of biomedical optics” Dyes can penetrate human skin and hair follicles up to 1.2 mm deep and the sebaceous gland can store dye; Indocyanine Green lotion was made for safe dyeing and monitoring.
34 citations,
September 2020 in “Clinical, cosmetic and investigational dermatology” Hyaluronic acid increases collagen synthesis safely, while poly-L-lactic acid may cause complications by affecting fibroblasts.
9 citations,
November 2000 in “Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE” Dyeing hair can help target and destroy hair follicles selectively.
5 citations,
February 1997 in “Bioorganic & Medicinal Chemistry” New compounds were made that effectively block a specific enzyme related to androgen conditions.
This in vitro study developed dermal papilla (DP) and vascularized DP (VASC-DP) models to investigate hair regression and loss mechanisms by mimicking senescence factors. The research identified TGF-β1 and FGF-18 as key regulators of hair cycle transitions, with TGF-β1 promoting the shift from anagen to catagen and FGF-18 advancing the cycle to a telogen-like phase. The study highlighted the role of vascularization in enhancing tissue physiology and modulating gene expression, with treatments like Minoxidil promoting hair growth by activating β-catenin signaling, while Doxorubicin induced hair follicle dystrophy. The findings suggest these models are valuable for exploring hair cycle dynamics and developing personalized therapies for hair loss.