Effect of Hyaluronic Acid and Poly-L-Lactic Acid Dermal Fillers on Collagen Synthesis: An In Vitro and In Vivo Study

    September 2020 in “ Clinical, cosmetic and investigational dermatology ”
    Larissa Rocha Bertelli Cabral, Lucas Novaes Teixeira, Rodrigo Pinto Gimenez, Ana Paula Dias Demasi, Rui Barbosa de Brito, Vera Cavalcanti de Araújo, Elizabeth Ferreira Martinez
    TLDR Hyaluronic acid increases collagen synthesis safely, while poly-L-lactic acid may cause complications by affecting fibroblasts.
    The study investigated the effects of hyaluronic acid (HA) and poly-L-lactic acid (PLLA) dermal fillers on collagen synthesis both in vitro and in vivo. In vitro, HA increased cell proliferation and type I collagen expression in human dermal fibroblasts, while PLLA reduced cell proliferation and viability. In vivo, involving 30 participants, HA led to higher type I collagen content and improved skin elasticity compared to PLLA, which caused inflammatory reactions. The study concluded that HA is more favorable for skin treatments due to its natural integration and minimal adverse effects, whereas PLLA's benefits are offset by its potential to cause clinical complications.
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