Maintaining Inducibility of Dermal Follicle Cells on Silk Fibroin/Sodium Alginate Scaffold for Enhanced Hair Follicle Regeneration

March 2021 in “ Biology ”

Kuo Dong, Xinyu Wang, Ying H. Shen, Yiyu Wang, Binbin Li, Cuiling Cai, Linyi Shen, Yajin Guo

silk fibroin sodium alginate dermal follicle cells hair follicle regeneration hair growth cell growth cell proliferation cell differentiation hair-inducing ability hair loss treatment

Studysummary This study found that silk fibroin/sodium alginate scaffolds seeded with dermal papilla cells may accelerate skin repair and hair follicle regeneration in a rat model. Our plain-language summary of this paper — not a Tressless recommendation.

A scaffold made of silk fibroin and sodium alginate has shown potential for enhancing hair follicle regeneration by maintaining the ability of dermal follicle cells to induce hair growth. The scaffold has been found to be effective in promoting cell growth, proliferation, and differentiation, and can restore hair-inducing ability. The study suggests that the scaffold has potential for use in hair loss treatment.

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In animal models, this study reported that a wound dressing combining quaternized chitin and silk fibroin significantly enhanced vascular reconstruction and hair follicle regeneration, approaching normal tissue levels.

research Characterization of Human Dermal Papilla Cells in Alginate Spheres

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This study found that alginate spheres maintain dermal papilla cells in a dormant state with increased trichogenecity, suggesting potential benefits for cell therapy in androgenic alopecia.

research Extracellular Matrix as a Regulator of Epidermal Stem Cell Fate

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research Impact of Substrate Stiffness on Dermal Papilla Aggregates in Microgels

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research Hair Germ Model In Vitro via Human Postnatal Keratinocyte-Dermal Papilla Interactions: Impact of Hyaluronic Acid

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This study found that while extracellular matrix components like hyaluronic acid promoted larger organoid formation, other matrix components hindered hair follicle germ assembly in an in vitro model.

research Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type

184 citations , November 2014 in “Developmental Cell”

This study identifies a bipotent stem cell in adult hair follicles that self-renews and contributes to dermal sheath and papilla cell populations, potentially aiding hair regrowth after injury, disease, or aging.

The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle

research The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle

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research Hair Follicle Signaling Networks: A Dermal Papilla–Centric Approach

28 citations , September 2013 in “Journal of Investigative Dermatology”

This research reviews the roles of dermal papilla signaling in hair follicle development and suggests new genetic tools could advance bioengineering therapies for alopecia, but it reports no new results.

research Mesenchymal–Epithelial Interactions During Hair Follicle Morphogenesis and Cycling

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research Dynamic Signals for Hair Follicle Development and Regeneration

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research Human Hair Follicle Regeneration Following Amputation and Grafting into the Nude Mouse

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