Impact of Substrate Stiffness on Dermal Papilla Aggregates in Microgels

    January 2018 in “ Biomaterials Science ”
    Justin Tan, Jie Kai Tee, Keat Onn Chou … Lifeng Kang
    Studysummary This study observed that dermal papilla cell aggregates showed increased viability and gene expression on softer 3D substrates, indicating the importance of substrate stiffness in cellular behavior.
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    Research cited in this study 16

    1. Keratin Network Modifications Lead to the Mechanical Stiffening of the Hair Follicle Fiber Proceedings of the National Academy of Sciences of the United States of America · 2016
    2. Differential Expression Between Human Dermal Papilla Cells from Balding and Non-Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia Journal of Investigative Dermatology · 2016
    3. Strategies to Enhance Epithelial-Mesenchymal Interactions for Human Hair Follicle Bioengineering Journal of Dermatological Science · 2013
    4. Human Induced Pluripotent Stem Cell-Derived Ectodermal Precursor Cells Contribute to Hair Follicle Morphogenesis In Vivo ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2013
    5. Scalable Production of Controllable Dermal Papilla Spheroids on PVA Surfaces and the Effects of Spheroid Size on Hair Follicle Regeneration Biomaterials · 2012
    6. Mesenchymal–Epithelial Interactions During Hair Follicle Morphogenesis and Cycling Seminars in Cell & Developmental Biology · 2012
    7. Large-Scale Cultivation of Transplantable Dermal Papilla Cellular Aggregates Using Microfabricated PDMS Arrays Acta Biomaterialia · 2010
    8. Current Technique of Follicular Unit Hair Transplantation Actas Dermo-Sifiliográficas · 2010
    9. Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair Developmental Cell · 2010
    10. Review of Hair Follicle Dermal Cells Journal of Dermatological Science · 2009
    11. Self-Assembly of Dermal Papilla Cells into Inductive Spheroidal Microtissues on Poly(Ethylene-Co-Vinyl Alcohol) Membranes for Hair Follicle Regeneration Biomaterials · 2008
    12. BMP Signaling in the Control of Skin Development and Hair Follicle Growth Differentiation · 2004
    13. Molecular Control of Epithelial-Mesenchymal Interactions During Hair Follicle Cycling ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2003
    14. Androgens and Alopecia Molecular and Cellular Endocrinology · 2002
    15. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    16. The Biology of Hair Follicles The New England Journal of Medicine · 1999

    Related research 3

    1. Effect of Orostachys Iwarenge Hara on the Proliferation of Dermal Papilla Cells Journal of Medicine and Life Science · 2010
    2. Clinical Observed Human Dermal Papilla Cells Conditioned Medium Treated Androgenetic Alopecia Chinese Journal of Aesthetic Medicine · 2009
    3. The In Vitro Properties of Dermal Papilla Cell Lines Established From Human Hair Follicles British Journal of Dermatology · 1986