Keratin Network Modifications Lead to the Mechanical Stiffening of the Hair Follicle Fiber

    May 2016 in “ Proceedings of the National Academy of Sciences of the United States of America ”
    Thomas Bornschlögl, Lucien Bildstein, S. Thibaut … Nawel Baghdadli
    Studysummary This study found that the mechanical stiffening of the human hair follicle along the first millimeter is linked to changes in the keratin network architecture and composition during keratinization.
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    Research cited in this study 14

    1. Mapping the Accessibility of the Disulfide Crosslink Network in the Wool Fiber Cortex Proteins Structure Function and Bioinformatics · 2014
    2. The Role of Disulfide Bond Formation in the Structural Transition Observed in the Intermediate Filaments of Developing Hair Journal of Structural Biology · 2012
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    4. Transglutaminase-3 Enzyme: A Putative Actor in Human Hair Shaft Scaffolding? ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2008
    5. Structural Changes in Trichocyte Intermediate Filaments During Transition from Reduced to Oxidized Form Journal of Structural Biology · 2007
    6. In Vivo Formation Steps of the Hard Alpha-Keratin Intermediate Filament Along a Hair Follicle: Evidence for Structural Polymorphism Journal of Structural Biology · 2006
    7. Human Hair Keratin-Associated Proteins International review of cytology · 2006
    8. Nanomechanical Characterization of Human Hair Using Nanoindentation and SEM Ultramicroscopy · 2005
    9. Hair Keratin Pattern in Human Hair Follicles Grown In Vitro Experimental dermatology · 2003
    10. The Catalog of Human Hair Keratins Journal of Biological Chemistry · 2001
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    4. Keratins of the Human Hair Follicle International review of cytology · 2005
    5. Hair Follicle Differentiation And Regulation The International Journal of Developmental Biology · 2004
    6. Hair Keratin Pattern in Human Hair Follicles Grown In Vitro Experimental dermatology · 2003