Mapping the Accessibility of the Disulfide Crosslink Network in the Wool Fiber Cortex

    November 2014 in “ Proteins Structure Function and Bioinformatics ”
    Santanu Deb‐Choudhury, Jeffrey E. Plowman, K L Narayana and T V Chowdary N V Rao … Duane P. Harland
    Studysummary In this study, researchers mapped cysteine accessibility in wool keratins and KAPs, revealing that certain cysteines in keratin end domains and Types I and II rod domains are accessible and likely involved in forming disulfide bonds.
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    Research cited in this study 6

    1. Bidirectional Binding Property of High Glycine–Tyrosine Keratin-Associated Protein Contributes to the Mechanical Strength and Shape of Hair Journal of structural biology · 2013
    2. The Role of Disulfide Bond Formation in the Structural Transition Observed in the Intermediate Filaments of Developing Hair Journal of Structural Biology · 2012
    3. Characterization of the Human Hair Keratin-Associated Protein 2 (KRTAP2) Gene Family Journal of Investigative Dermatology · 2012
    4. An Updated Nomenclature for Keratin-Associated Proteins International Journal of Biological Sciences · 2012
    5. Human Hair Keratin-Associated Proteins: Sequence Regularities and Structural Implications Journal of Structural Biology · 2006
    6. The Intermediate Filament Architecture as Determined by X-Ray Diffraction Modeling of Hard Alpha-Keratin Biophysical Journal · 2004

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