Fabrication and Characterization of Epithelial Scaffolds for Hair Follicle Regeneration

May 2012 in “ Tissue Engineering and Regenerative Medicine ”

Jiwon Oh, Jeong Il Choi, Min-Hye Kim, Syed Izhar Haider Abdi, Hui-Chong Lau, Moon Kyu Kim, Jeong Mook Lim

epithelial scaffolds hair follicle regeneration bladder submucosal membrane BSM sponge keratin fiber sheet mouse newborn epithelial skin scaffold NESS melanocytes dermal papilla sphere hyaluronic acid sheet human outer root sheath keratinocytes follicular epithelial cell physiology dermal papilla hyaluronic acid keratinocytes follicular cells

Studysummary This study demonstrated the potential of epithelial cell scaffolds fabricated with various materials for effective hair regeneration, highlighting their promising application in tissue engineering for alopecia treatment. Our plain-language summary of this paper — not a Tressless recommendation.

In 2012, researchers developed and tested three types of epithelial scaffolds for hair follicle regeneration: bladder submucosal membrane (BSM) sponge, keratin fiber sheet, and mouse newborn epithelial skin scaffold (NESS). The BSM sponge activated melanocytes when the inductive dermal papilla sphere was inserted, indicating potential for hair regeneration. The keratin fiber sheet was found to enhance cell spreading and adhesion more effectively than the hyaluronic acid sheet. Human outer root sheath keratinocytes formed a cluster on the NESS, suggesting it could enhance the functional properties of human epithelial cells. These findings suggested that these scaffolds could be used to study follicular epithelial cell physiology and properties in vitro, and potentially aid in hair regeneration.

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Research cited in this study

17 / 17 results

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The researchers reported that DHT-inducible DKK-1 may play a significant role in DHT-driven balding by inhibiting hair follicle cell growth and promoting apoptosis in androgenetic alopecia.

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research The Natural History of Androgenetic Alopecia

12 citations , January 2005 in “Journal of Cosmetic Dermatology”

This review discusses the natural progression of androgenetic alopecia and potential factors influencing its long-term prognosis, reporting no new clinical results.

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155 citations , August 2003 in “Journal Of Experimental Zoology Part B: Molecular And Developmental Evolution”

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This study found that the volume of a hair follicle's dermal papilla is strongly correlated with its size, primarily due to the number of cells it contains and the volume of extracellular matrix.