Increased DHT Levels in Androgenic Alopecia Selected to Protect Men from Prostate Cancer

    January 2014 in “ Medical Hypotheses ”
    Shiva Bhargava
    Studysummary This article discusses the hypothesis that mechanisms driving androgenic alopecia may reduce the risk and proliferation of prostate cancer by increasing prostaglandin D2 levels but presents no new clinical findings.
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    Research cited in this study 20

    1. Relationship of Early-Onset Baldness to Prostate Cancer in African-American Men Cancer Epidemiology, Biomarkers & Prevention · 2013
    2. Androgenetic Alopecia at Various Ages and Prostate Cancer Risk in an Equal-Access Multiethnic Case-Control Series of Veterans Cancer Causes & Control · 2013
    3. Androgenetic Alopecia and Risk of Prostate Cancer: A Systematic Review and Meta-Analysis Journal of The American Academy of Dermatology · 2013
    4. Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia Science Translational Medicine · 2012
    5. Male Pattern Baldness and the Risk of Prostate Cancer Annals of Oncology · 2011
    6. Androgenic Alopecia Is Not Useful as an Indicator of Men at High Risk of Prostate Cancer European Journal of Cancer · 2010
    7. Male Pattern Baldness and Prostate Cancer Risk in a Population-Based Case-Control Study Cancer epidemiology · 2010
    8. Recent Positive Selection of a Human Androgen Receptor/Ectodysplasin A2 Receptor Haplotype and Its Relationship to Male Pattern Baldness Human Genetics · 2009
    9. Baldness, Benign Prostate Hyperplasia, Prostate Cancer, and Androgen Levels The Aging Male · 2008
    10. Androgenic Alopecia May Have Evolved to Protect Men from Prostate Cancer by Increasing Skin Exposure to Ultraviolet Radiation Medical Hypotheses · 2007
    11. Higher Levels of Steroidogenic Acute Regulatory Protein and Type I 3β-Hydroxysteroid Dehydrogenase in the Scalp of Men with Androgenetic Alopecia Journal of Investigative Dermatology · 2006
    12. Hair Growth Inhibition by Psychoemotional Stress: A Mouse Model for Neural Mechanisms in Hair Growth Control Experimental Dermatology · 2005
    13. Evaluation and Treatment of Male and Female Pattern Hair Loss Journal of The American Academy of Dermatology · 2004
    14. Patients With a Large Prostate Show a Higher Prevalence of Androgenetic Alopecia Archives of Dermatological Research · 2004
    15. The Distribution of Estrogen Receptor Beta Is Distinct to That of Estrogen Receptor Alpha and the Androgen Receptor in Human Skin and the Pilosebaceous Unit Journal of Investigative Dermatology Symposium Proceedings · 2003
    16. The Genetics of Androgenetic Alopecia Clinics in Dermatology · 2001
    17. Risk Factors for Prostate Cancer: A Case-Control Study in Greece International Journal of Cancer · 1999
    18. Prevalence of Male Pattern Hair Loss in 18–49 Year Old Men Dermatologic Surgery · 1998
    19. Fortnightly Review: Male Pattern Androgenetic Alopecia BMJ · 1998
    20. Association of Benign Prostatic Hyperplasia with Male Pattern Baldness Urology · 1998