Chronic Restraint Stress Inhibits Hair Growth via Substance P Mediated by Reactive Oxygen Species in Mice

    April 2013 in “ PLoS ONE ”
    Nan Liu, Lin‐Hui Wang, Lingling Guo … Guo‐Xing Zhang
    Studysummary The researchers reported that reactive oxygen species regulate the stress-induced SP-Mast cell pathway, which might support using antioxidants to treat stress-related hair loss.
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    Research cited in this study 19

    1. Hair Follicle as a Target of Stress Hormones and Autoimmune Reactions Journal of Dermatological Science · 2010
    2. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    3. Oxidative Stress in Aging of Hair International Journal of Trichology · 2009
    4. Probing the Effects of Stress Mediators on the Human Hair Follicle American Journal of Pathology · 2007
    5. Foot Shock Stress Prolongs the Telogen Stage of the Spontaneous Hair Cycle in a Non-Depilated Mouse Model Experimental Dermatology · 2007
    6. Neuroimmunology of Stress: Skin Takes Center Stage Journal of Investigative Dermatology · 2006
    7. Towards A Free Radical Theory Of Graying: Melanocyte Apoptosis In The Aging Human Hair Follicle As An Indicator Of Oxidative Stress Induced Tissue Damage ˜The œFASEB journal · 2006
    8. Biology of the Hair Follicle: The Basics Seminars in Cutaneous Medicine and Surgery · 2006
    9. Hair Growth Inhibition by Psychoemotional Stress: A Mouse Model for Neural Mechanisms in Hair Growth Control Experimental Dermatology · 2005
    10. Aging of Hair Journal of Cosmetic Dermatology · 2005
    11. Mast Cell Deficient and Neurokinin-1 Receptor Knockout Mice Are Protected from Stress-Induced Hair Growth Inhibition Journal of Molecular Medicine · 2005
    12. Stress Inhibits Hair Growth in Mice by Inducing Premature Catagen Development and Harmful Perifollicular Inflammatory Events via Neuropeptide Substance P-Dependent Pathways American Journal of Pathology · 2003
    13. Indications for a Brain-Hair Follicle Axis: Inhibition of Keratinocyte Proliferation and Up-Regulation of Keratinocyte Apoptosis in Telogen Hair Follicles by Stress and Substance P The FASEB Journal · 2001
    14. Towards a Molecular Understanding of Hair Loss and Its Treatment Trends in Molecular Medicine · 2001
    15. Antioxidants and Lipid Peroxidation Status in the Blood of Patients with Alopecia Cell biochemistry and function · 2000
    16. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    17. A Murine Model for Inducing and Manipulating Hair Follicle Regression: Effects of Dexamethasone and Cyclosporin A Journal of Investigative Dermatology · 1994
    18. Melanogenesis Is Coupled to Murine Anagen: New Concepts for the Role of Melanocytes and Regulation of Melanogenesis in Hair Growth ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1993
    19. Melanogenesis Is Coupled to Murine Anagen: Toward New Concepts for the Role of Melanocytes and the Regulation of Melanogenesis in Hair Growth ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1993