Hair Growth-Promotion Effects at the Cellular Level and Antioxidant Activity of the Plant-Based Extract Phyllotex

The study conducted in September 2021 found that the plant-based extract Phyllotex™ significantly promoted hair growth at the cellular level and exhibited strong antioxidant activity. It increased the proliferation of dermal papilla cells, which are crucial for hair growth and regeneration, and protected hair follicles from oxidative stress damage. The study also found that Phyllotex™ could potentially treat androgenetic alopecia in both males and females. It stimulated cell proliferation, increased the phosphorylated form of ERK1/2 (a marker for cell proliferation), and suppressed TGF-β1 expression, a factor involved in hair loss, without blocking DHT production. After 24 hours of incubation with Phyllotex™, female hair dermal papilla cells increased up to 48% and male cells up to 36.5%. The formula also increased the proliferation of HaCaT cells up to 118% over the control. The study concluded that Phyllotex™ could be a potential hair growth-promoting agent due to its multifactorial composition.