TLDR CHIR99021 helps create human skin with hair follicles, offering hope for hair loss treatments.
The study demonstrated that the Wnt signaling activator CHIR99021, in combination with a 3D spheroid culture method, enhanced the expression of dermal papilla (DP) signature genes, which are crucial for hair-inducing ability. The floating drop method was identified as the most effective 3D culture technique for maintaining these gene expressions. The CHIR99021-stimulated DP spheroids successfully contributed to the formation of reconstituted human skin enriched with hair follicles. Additionally, injected human dermal sheath cup (DSC) cells showed proper localization in the generated skin, indicating functional integration into hair follicles. This research provided a promising approach for generating human skin with functional hair follicles, potentially advancing treatments for hair loss.
256 citations,
October 2013 in “Proceedings of the National Academy of Sciences of the United States of America” Growing human skin cells in a 3D environment can stimulate new hair growth.
131 citations,
July 2009 in “Experimental Dermatology” The document concludes that specific cells are essential for hair growth and more research is needed to understand how to maintain their hair-inducing properties.
208 citations,
December 2003 in “Journal of Investigative Dermatology” Certain cells from hair follicles can create new hair and contribute to hair growth when implanted in mice.
277 citations,
June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” Epithelial-mesenchymal interactions control hair growth cycles through specific molecular signals.
January 2022 in “Journal of St. Marianna University” Substances from human hair cells can affect hair loss-related genes, potentially leading to new treatments for baldness.
15 citations,
April 2014 in “Experimental Dermatology” Scientists developed a system to study human hair growth using skin cells, which could help understand hair development and improve skin substitutes for medical use.
321 citations,
December 2009 in “Journal of Dermatological Science” Dermal cells are key in controlling hair growth and could potentially be used in hair loss treatments, but more research is needed to improve hair regeneration methods.
January 2003 in “Chinese Journal of Reparative and Reconstructive Surgery” Dermal papilla cells can help form hair follicles and produce hair.
66 citations,
August 2001 in “Experimental Dermatology” Human hair follicle cells can grow hair when put into mouse skin if they stay in contact with mouse cells.
57 citations,
November 1998 in “Wound Repair and Regeneration” Hair papilla cells can create and regenerate hair bulbs under the right conditions.
