Regenerative Potential of Adipose Tissue-Derived Exosomes in Treating Hair Shaft Abnormalities: A Case Report

    January 2025 in “ Case Reports in Dermatological Medicine ”
    Mohammad Ali Nilforoushzadeh, Amirhossein Heidari, Nazila Heidari, Niloufar Najar Nobari
    Studysummary This report describes an eight-year-old girl with severe hair shaft abnormalities who showed significant improvement after a single session of adipose tissue–derived exosome therapy, highlighting its potential as an innovative treatment option and the need for further studies to confirm its efficacy and safety.
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    Research cited in this study 11

    1. Mesenchymal Stem Cell Exosome Therapy for Acquired Trichorrhexis Nodosa: A Case Series Journal of Cosmetic Dermatology · 2024
    2. Exosomes Derived Stem Cells as a Modern Therapeutic Approach for Skin Rejuvenation and Hair Regrowth Regenerative Therapy · 2024
    3. Exosomes Derived From Umbilical Cord Mesenchymal Stem Cells Promote Hair Regrowth in Alopecia Areata Cell Biology International · 2023
    4. Hair Shaft Disorders In Children: An Update Indian Dermatology Online Journal · 2023
    5. Exosome Therapy in Hair Regeneration: A Literature Review of the Evidence, Challenges, and Future Opportunities Journal of cosmetic dermatology · 2022
    6. Effects of Adipose-Derived Stem Cells and Platelet-Rich Plasma Exosomes on the Inductivity of Hair Dermal Papilla Cells PubMed · 2021
    7. Regulation of Hair Follicle Development by Exosomes Derived from Dermal Papilla Cells Biochemical and Biophysical Research Communications · 2018
    8. Topical Cetirizine and Oral Vitamin D: A Valid Treatment for Hypotrichosis Caused by Ectodermal Dysplasia JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology · 2016
    9. Prognosis and Management of Congenital Hair Shaft Disorders with Fragility—Part I Pediatric Dermatology · 2016
    10. Signaling Involved in Hair Follicle Morphogenesis and Development International Journal of Molecular Sciences · 2014
    11. Hair Shaft Abnormalities: Clues to Diagnosis and Treatment Dermatology · 2005