Topical Cetirizine and Oral Vitamin D: A Valid Treatment for Hypotrichosis Caused by Ectodermal Dysplasia

August 2016 in “ JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology ”

Alfredo Rossi, Emanuele Miraglia, Maria Caterina Fortuna, Stefano Calvieri, Sandra Giustini

topical cetirizine oral vitamin D hypotrichosis ectodermal dysplasia vellus hair terminal hair trichoscopy cetirizine vitamin D

From the encyclopedia

Cetirizine →

popular antihistamine showing promise for hair loss as an anti-inflammatory and prostaglandin inhibitor

Vitamin D →

vitamin you should probably be taking for general health might also help your hair a little

Studysummary This case report observed that after 6 months of treatment with topical cetirizine and oral vitamin D, hair density and quality improved in three girls with congenital hypotrichosis due to ectodermal dysplasia.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

In a study from 2016, three girls aged 9, 5, and 6 with congenital hypotrichosis due to ectodermal dysplasia were treated with a combination of topical cetirizine solution (2 mL once daily) and oral vitamin D supplementation (1000 IU daily). After 6 months of treatment, all patients experienced an increase in scalp hair density, with vellus hair being replaced by terminal hair. The hair regrowth was assessed both clinically and through trichoscopy. The study concluded that the combination of topical cetirizine and oral vitamin D could be an effective treatment for congenital hypotrichosis associated with ectodermal dysplasia.

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Research cited in this study

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Characterization of X-Linked Hypohidrotic Ectodermal Dysplasia Hair and Sweat Gland Phenotypes Using Phototrichogram Analysis and Live Confocal Imaging

research Characterization of X-Linked Hypohidrotic Ectodermal Dysplasia Hair and Sweat Gland Phenotypes Using Phototrichogram Analysis and Live Confocal Imaging

15 citations , May 2013 in “American Journal of Medical Genetics - Part A”

People with X-linked hypohidrotic ectodermal dysplasia have no sweat ducts and less, thinner hair.

research Topical Minoxidil Treatment for Congenital Alopecia in Hypohidrotic Ectodermal Dysplasia

12 citations , March 2013

This report describes a case where a 4-year-old boy with congenital alopecia due to hypohidrotic ectodermal dysplasia experienced significant hair growth after using topical minoxidil.

research Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia

205 citations , March 2012 in “Science Translational Medicine”

PGD2 stops hair growth and is higher in bald men with AGA.

Alopecia in Congenital Hidrotic Ectodermal Dysplasia Responding to Treatment with a Combination of Topical Minoxidil and Tretinoin

research Alopecia in Congenital Hidrotic Ectodermal Dysplasia Responding to Treatment with a Combination of Topical Minoxidil and Tretinoin

20 citations , January 2009 in “International Journal of Dermatology”

This case report describes a patient with Clouston's syndrome and alopecia who responded positively to topical treatment with minoxidil and tretinoin.

research Lack of the Vitamin D Receptor Is Associated with Reduced Epidermal Differentiation and Hair Follicle Growth

180 citations , January 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study observed that vitamin D receptor knockout mice exhibit impaired epidermal differentiation and progressive hair loss, suggesting the importance of the vitamin D receptor in normal skin and hair follicle development.

research Multiple Roles for Activated LEF/TCF Transcription Complexes During Hair Follicle Development and Differentiation

990 citations , October 1999 in “Development”

This study found that LEF1/TCF3 is necessary but not sufficient for TOPGAL activation in hair follicle development, indicating complex regulation in the skin.