Exosomes Derived From Umbilical Cord Mesenchymal Stem Cells Promote Hair Regrowth in Alopecia Areata

November 2023 in “ Cell Biology International ”

HU Shou-song, Jiayi Zhang, Qingqing Ji, Sai‐Sai Xie, Jingting Jiang, Haitao Ni, Xi He, Yadong Yang, Minjuan Wu

exosomes umbilical cord mesenchymal stem cells uMSCs alopecia areata hair follicular keratinocyte autoimmune attack hair follicle hair regrowth stem cells AA hair loss

TLDR Tiny particles from umbilical cord stem cells may help hair grow back in a type of hair loss.

The research article discusses the potential of exosomes derived from human umbilical cord mesenchymal stem cells (uMSCs) in promoting hair regrowth in alopecia areata (AA), a genetic disease causing hair loss due to an autoimmune attack on the hair follicle. The study highlights the therapeutic potential of uMSCs, which are easier to isolate and cultivate than MSCs from bone marrow or adipose tissue. The researchers investigated the effects of these exosomes on AA mice, suggesting that due to their easy isolation, cultivation, preparation, and storage, uMSCs and their exosomes could be used for research and clinical treatment of AA.

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Exosomes Derived From Umbilical Cord Mesenchymal Stem Cells Promote Hair Regrowth in Alopecia Areata

Research cited in this study

research Dermal Papilla Cell-Derived Exosomes Regulate Hair Follicle Stem Cell Proliferation via LEF1

research JAM-A Facilitates Hair Follicle Regeneration in Alopecia Areata Through Functioning as CeRNA to Protect VCAN Expression in Dermal Papilla Cells

research Applications of the Regenerative Capacity of Platelets in Modern Medicine

research Building and Maintaining the Skin

research Hair Transplantation: Basic Overview

research Corticosterone Inhibits GAS6 to Govern Hair Follicle Stem-Cell Quiescence

research Rescuing Key Native Traits in Cultured Dermal Papilla Cells for Human Hair Regeneration

research Alopecia Areata: A Comprehensive Review of Pathogenesis and Management

research Mesenchymal Stem Cells With Modification of Junctional Adhesion Molecule A Induce Hair Formation

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