Dermal Papilla Cell-Derived Exosomes Regulate Hair Follicle Stem Cell Proliferation via LEF1

    Jiali Li, Bohao Zhao, Shuyu Yao, Yingying Dai, Xiyu Zhang, Naisu Yang, Zhiyuan Bao, Jiawei Cai, Yang Chen, Xinsheng Wu
    Image of study
    TLDR Exosomes from skin cells can boost hair growth by stimulating a gene called LEF1.
    The study investigated the role of exosomes derived from dermal papilla cells (DPC-Exos) in hair follicle stem cell (HFSC) proliferation. It was found that DPC-Exos increased cell viability and reduced apoptosis in HFSCs. RNA sequencing identified 3702 differentially expressed genes in DPC-Exos-treated HFSCs, including LEF1, a gene associated with hair follicle development. Overexpression of LEF1 increased the expression of hair follicle development-related genes and proteins, enhanced HFSC proliferation, and reduced HFSC apoptosis. Conversely, knockdown of LEF1 reversed these effects. The study concluded that DPC-Exos can regulate HFSC proliferation by stimulating LEF1, providing new insights into hair follicle growth and development regulatory mechanisms.
    Discuss this study in the Community →

    Research cited in this study

    22 / 22 results

    Related Community Posts Join

    6 / 1000+ results

    Similar Research

    6 / 1000+ results