Lef1 Contributes to the Differentiation of Bulge Stem Cells by Nuclear Translocation and Cross-Talk with the Notch Signaling Pathway

January 2013 in “ International Journal of Medical Sciences ”

Yi Zhang, Jin Yü, Chunying Shi, Yaqin Huang, Yun Wang, Yang Tian, Jin Yang

Lef1 bulge stem cells anagen phase β-catenin c-myc jagged1 Wnt signaling pathway Notch signaling pathway

Studysummary This study reports that Lef1 plays a crucial role in promoting bulge stem cell differentiation towards hair fate by activating β-catenin and downstream signaling pathways during hair follicle development.

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This study found that in vitro, cultured bulge cells from human hair follicles possess properties of primitive cells, supporting the hypothesis that hair follicle stem cells reside in the bulge area.

research Dermal Papilla-Induced Hair Differentiation of Adult Epithelial Stem Cells from Human Skin

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In this study, repressing β-catenin/Lef1 signalling in mouse epidermis led to progressive hair loss, dermal cysts, and spontaneous skin tumors with sebaceous differentiation, indicating altered keratinocyte differentiation and potential tumourigenic processes.

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research Contrasting Localization of c-Myc with Other Myc Superfamily Transcription Factors in the Human Hair Follicle and During the Hair Growth Cycle

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