Lagerstroemia Indica Extract Regulates Human Hair Dermal Papilla Cell Growth and Degeneration via Modulation of β-Catenin, Stat6, and TGF-β Signaling Pathway

May 2022 in “ Journal of Cosmetic Dermatology ”

Byunghyun Kim, Myong Ki Kim, Bu Young Choi

Lagerstroemia indica hair dermal papilla cells β-catenin Stat6 TGF-β Wnt-β-catenin JAK3-STAT6 TGF-β1-Smad hair follicle hair tonic hair growth hair loss prevention crepe myrtle hair growth tonic hair loss prevention tonic

TLDR Lagerstroemia indica extract can help prevent hair loss and promote hair growth.

The study investigated the effects of Lagerstroemia indica extract on hair growth and hair loss prevention. It was found that L. indica significantly promoted the proliferation of human hair follicle dermal papilla cells and inhibited hair follicular degeneration. This was achieved through the modulation of the Wnt-β-catenin, JAK3-STAT6, and TGF-β1-Smad signaling pathways. A clinical trial involving 24 healthy volunteers showed a statistically significant increase in total hair count after 24 weeks of using a hair tonic enriched with L. indica. The findings suggested that L. indica extract could be developed as a novel functional cosmetic for preventing hair loss.

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