Finasteride and Erectile Dysfunction in Patients with Benign Prostatic Hyperplasia or Male Androgenetic Alopecia

    August 2018 in “ The World Journal of Men's Health ”
    Yu Seob Shin, Keshab Kumar Karna, Bo Youl Choi, Jong Chun Park
    Studysummary This review summarized existing research on finasteride and erectile dysfunction, finding a correlation between finasteride use for benign prostatic hyperplasia and ED, but not strongly for male androgenetic alopecia.
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    Research cited in this study 28

    1. Protective Effect of DA-9401 in Finasteride-Induced Apoptosis in Rat Testis: Inositol Requiring Kinase 1 and c-Jun N-Terminal Kinase Pathway Drug Design Development and Therapy · 2017
    2. Erectile Dysfunction in Young Men: A Review of Prevalence and Risk Factors Sexual Medicine Reviews · 2017
    3. Sexual Dysfunction in Subjects Treated with Inhibitors of 5α-Reductase for Benign Prostatic Hyperplasia: A Comprehensive Review and Meta-Analysis International Journal of Andrology · 2017
    4. Negative Impact of Testosterone Deficiency and 5α-Reductase Inhibitors Therapy on Metabolic and Sexual Function in Men Advances in Experimental Medicine and Biology · 2017
    5. Risk of Erectile Dysfunction Associated with Use of 5-Alpha Reductase Inhibitors for Benign Prostatic Hyperplasia or Alopecia: Population-Based Studies Using the Clinical Practice Research Datalink BMJ · 2016
    6. Effect of 5α-Reductase Inhibitors on Sexual Function: A Meta-Analysis and Systematic Review of Randomized Controlled Trials The Journal of Sexual Medicine · 2016
    7. An Observational Retrospective Evaluation of 79 Young Men with Long-Term Adverse Effects After Use of Finasteride Against Androgenetic Alopecia International Journal of Andrology · 2016
    8. Randomized Questionnaire-Based Case-Control Research Study on Evaluation of Sexual Function in Indian Patients Taking Oral Finasteride for Androgenetic Alopecia Dermatology and therapy · 2015
    9. Finasteride, Not Tamsulosin, Increases Severity of Erectile Dysfunction and Decreases Testosterone Levels in Men With Benign Prostatic Hyperplasia Hormone Molecular Biology and Clinical Investigation · 2015
    10. Persistent Sexual Dysfunction and Depression in Finasteride Users for Male Pattern Hair Loss: A Serious Concern or Red Herring? PubMed · 2014
    11. Immunohistochemical Evaluation of Androgen Receptor and Nerve Structure Density in Human Prepuce from Patients with Persistent Sexual Side Effects after Finasteride Use for Androgenetic Alopecia PLOS ONE · 2014
    12. Persistent Sexual, Emotional, and Cognitive Impairment Post-Finasteride American Journal of Men's Health · 2014
    13. The Dark Side of 5α-Reductase Inhibitors' Therapy: Sexual Dysfunction, High Gleason Grade Prostate Cancer, and Depression Korean Journal of Urology · 2014
    14. Persistent Sexual and Nonsexual Adverse Effects of Finasteride in Younger Men Sexual medicine reviews · 2013
    15. Organic Causes of Erectile Dysfunction in Men Under 40 Urologia Internationalis · 2013
    16. Long-Term Oral Administration of 5α-Reductase Inhibitor Attenuates Erectile Function by Inhibiting Autophagy and Promoting Apoptosis of Smooth Muscle Cells in Corpus Cavernosum of Aged Rats Urology · 2013
    17. Decreased Alcohol Consumption Among Former Male Users of Finasteride with Persistent Sexual Side Effects: A Preliminary Report Alcoholism: Clinical and Experimental Research · 2013
    18. Effects of 5-Alpha Reductase Inhibitors on Erectile Function, Sexual Desire, and Ejaculation Expert Opinion on Drug Safety · 2012
    19. 5α-Reductases in Human Physiology: An Unfolding Story Endocrine Practice · 2012
    20. Effects of Oral Finasteride on Erectile Function in a Rat Model The Journal of Sexual Medicine · 2012
    21. Persistent Sexual Side Effects of Finasteride for Male Pattern Hair Loss The Journal of Sexual Medicine · 2011
    22. Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients The Journal of Sexual Medicine · 2010
    23. Human Type 3 5α-Reductase Is Expressed in Peripheral Tissues at Higher Levels Than Types 1 and 2 and Its Activity Is Potently Inhibited by Finasteride and Dutasteride Hormone Molecular Biology and Clinical Investigation · 2010
    24. Finasteride 5mg and Sexual Side Effects: How Many Are Related to a Nocebo Phenomenon? The Journal of Sexual Medicine · 2007
    25. The Effect of 5α-Reductase Inhibition with Dutasteride and Finasteride on Semen Parameters and Serum Hormones in Healthy Men The Journal of Clinical Endocrinology and Metabolism · 2007
    26. The Importance of Dual 5α-Reductase Inhibition in the Treatment of Male Pattern Hair Loss: Results of a Randomized Placebo-Controlled Study of Dutasteride Versus Finasteride Journal of The American Academy of Dermatology · 2006
    27. Prevalence of Male and Female Pattern Hair Loss in Maryborough Journal of Investigative Dermatology Symposium Proceedings · 2005
    28. Androgenetic Alopecia in Men Aged 40-69 Years: Prevalence and Risk Factors British Journal of Dermatology · 2003

    Related research 7

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    2. The Impact of 5α-Reductase Inhibitor Use for Male Pattern Hair Loss on Men's Health Current Urology Reports · 2018
    3. Sexual Adverse Effects of Finasteride 1mg for Treatment of Androgenic Alopecia in Men Scripta Scientifica Vox Studentium · 2017
    4. Oral Finasteride Presents With Sexual-Unrelated Withdrawal in Long-Term Treated Androgenic Alopecia in Men PubMed · 2015
    5. Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients The Journal of Sexual Medicine · 2010
    6. Finasteride 5 mg and Sexual Side Effects: How Many Are Related to a Nocebo Phenomenon? Sexologies · 2008
    7. Finasteride 5mg and Sexual Side Effects: How Many Are Related to a Nocebo Phenomenon? The Journal of Sexual Medicine · 2007