Protective Effect of DA-9401 in Finasteride-Induced Apoptosis in Rat Testis: Inositol Requiring Kinase 1 and c-Jun N-Terminal Kinase Pathway

October 2017 in “ Drug Design Development and Therapy ”

Kiran Kumar Soni, Yu Seob Shin, Bo Youl Choi, Keshab Kumar Karna, Hyung Sik Kim, Sung Koo Lee, Chul Sung Kim, Jong Chun Park

finasteride DA-9401 apoptosis inositol requiring kinase 1 c-Jun N-terminal kinase 5α-reductase inhibitors hypothalamic-pituitary-testicular axis Propecia

TLDR DA-9401 helps protect rat testis from finasteride damage.

The study investigated the protective effect of DA-9401 on finasteride-induced apoptosis in rat testis. Finasteride caused infertility and apoptosis in testicular tissue, but DA-9401 was found to attenuate these effects. The study suggests that DA-9401 may have a protective effect against finasteride-induced apoptosis in rat testis through the inositol requiring kinase 1 and c-Jun N-terminal kinase pathway. Further studies are needed to understand the interaction between 5α-reductase inhibitors and DA-9401 in the hypothalamic-pituitary-testicular axis in humans.

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9 / 9 results

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2 / 2 results

research Protective Effect of DA-9401 in Finasteride-Induced Apoptosis in Rat Testis: Inositol Requiring Kinase 1 and c-Jun N-Terminal Kinase Pathway

18 citations , October 2017 in “Drug Design Development and Therapy”

DA-9401 helps protect rat testis from finasteride damage.

research Effect of finasteride, a 5 alpha-reductase inhibitor, on serum gonadotropins in normal men.

30 citations , August 1992 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride doesn't affect hormone levels in normal men.