Protective Effect of DA-9401 in Finasteride-Induced Apoptosis in Rat Testis: Inositol Requiring Kinase 1 and c-Jun N-Terminal Kinase Pathway

October 2017 in “ Drug Design Development and Therapy ”

Kiran Kumar Soni, Yu Seob Shin, Bo Youl Choi, Keshab Kumar Karna, Hyung Sik Kim, Sung Koo Lee, Chul Sung Kim, Jong Chun Park

finasteride DA-9401 apoptosis inositol requiring kinase 1 c-Jun N-terminal kinase 5α-reductase inhibitors hypothalamic-pituitary-testicular axis Propecia

TLDR DA-9401 helps protect rat testis from finasteride damage.

The study investigated the protective effect of DA-9401 on finasteride-induced apoptosis in rat testis. Finasteride caused infertility and apoptosis in testicular tissue, but DA-9401 was found to attenuate these effects. The study suggests that DA-9401 may have a protective effect against finasteride-induced apoptosis in rat testis through the inositol requiring kinase 1 and c-Jun N-terminal kinase pathway. Further studies are needed to understand the interaction between 5α-reductase inhibitors and DA-9401 in the hypothalamic-pituitary-testicular axis in humans.

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Research cited in this study

9 / 9 results

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Related Research

2 / 2 results

Protective Effect of DA-9401 in Finasteride-Induced Apoptosis in Rat Testis: Inositol Requiring Kinase 1 and c-Jun N-Terminal Kinase Pathway

research Protective Effect of DA-9401 in Finasteride-Induced Apoptosis in Rat Testis: Inositol Requiring Kinase 1 and c-Jun N-Terminal Kinase Pathway

18 citations, October 2017 in “Drug Design Development and Therapy”

DA-9401 helps protect rat testis from finasteride damage.

research Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Serum Gonadotropins in Normal Men

30 citations, August 1992 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride doesn't affect hormone levels in normal men.

Protective Effect of DA-9401 in Finasteride-Induced Apoptosis in Rat Testis: Inositol Requiring Kinase 1 and c-Jun N-Terminal Kinase Pathway

Research cited in this study

research Finasteride and Sexual Side Effects

research Finasteride-Induced Secondary Infertility Associated with Sperm DNA Damage

research Spermatozoa and Chronic Treatment with Finasteride: A TEM and FISH Study

research The Importance of Dual 5α-Reductase Inhibition in the Treatment of Male Pattern Hair Loss: Results of a Randomized Placebo-Controlled Study of Dutasteride Versus Finasteride

research Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor

research Effects of the Chronic Use of Finasteride on Testicular Weight and Spermatogenesis in Wistar Rats

research Effects of the 5α-Reductase Inhibitor Finasteride on Serum Levels of Gonadal, Adrenal, and Hypophyseal Hormones and Its Clinical Significance: A Prospective Clinical Study

research Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Serum Gonadotropins in Normal Men

research Decreased Fertility in Male Rats Administered the 5α-Reductase Inhibitor, Finasteride, Due to Deficits in Copulatory Plug Formation

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