Protective Effect of DA-9401 in Finasteride-Induced Apoptosis in Rat Testis: Inositol Requiring Kinase 1 and c-Jun N-Terminal Kinase Pathway

    October 2017 in “ Drug Design Development and Therapy ”
    Kiran Kumar Soni, Yu Seob Shin, Bo Youl Choi … Jong Chun Park
    Studysummary The study found that finasteride increased endoplasmic reticulum stress and reduced fertility in rats, effects that were alleviated by the administration of DA-9401.
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    Research cited in this study 10

    1. Finasteride and Sexual Side Effects Indian Dermatology Online Journal · 2012
    2. Finasteride-Induced Secondary Infertility Associated with Sperm DNA Damage Fertility and Sterility · 2011
    3. Spermatozoa and Chronic Treatment with Finasteride: A TEM and FISH Study Archives of Andrology · 2007
    4. The Importance of Dual 5α-Reductase Inhibition in the Treatment of Male Pattern Hair Loss: Results of a Randomized Placebo-Controlled Study of Dutasteride Versus Finasteride Journal of The American Academy of Dermatology · 2006
    5. 5-Alpha-Reductase 2 Inhibition Impairs Brain Defeminization of Male Rats: Reproductive Aspects Pharmacology Biochemistry and Behavior · 2005
    6. Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 2004
    7. Effects of the Chronic Use of Finasteride on Testicular Weight and Spermatogenesis in Wistar Rats BJUI · 2002
    8. Effects of the 5α-Reductase Inhibitor Finasteride on Serum Levels of Gonadal, Adrenal, and Hypophyseal Hormones and Its Clinical Significance: A Prospective Clinical Study Steroids · 1998
    9. Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Serum Gonadotropins in Normal Men The Journal of Clinical Endocrinology and Metabolism · 1992
    10. Decreased Fertility in Male Rats Administered the 5α-Reductase Inhibitor, Finasteride, Due to Deficits in Copulatory Plug Formation Reproductive Toxicology · 1991

    Related research 2

    1. Protective Effect of DA-9401 in Finasteride-Induced Apoptosis in Rat Testis: Inositol Requiring Kinase 1 and c-Jun N-Terminal Kinase Pathway Drug Design Development and Therapy · 2017
    2. Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Serum Gonadotropins in Normal Men The Journal of Clinical Endocrinology and Metabolism · 1992