Modeling of Solar UV-Induced Photodamage on the Hair Follicles in Human Skin Organoids

The study used human induced pluripotent stem cell-derived skin organoids to investigate the effects of solar UV (sUV) exposure on hair follicles. It found that sUV exposure caused skin barrier disruption, inflammatory response, and structural damage to hair follicles. However, the application of exosomes isolated from human umbilical cord blood-derived mesenchymal stem cells effectively alleviated these effects by inhibiting NF-κB activation, thereby promoting hair follicle regeneration. The study also found that sUV exposure led to increased apoptosis and a transition into the catagen phase, associated with hair loss. The research suggests that these exosomes could be a potential therapeutic agent for ameliorating UV-induced damage of hair follicles.