Hair Follicle Disruption Facilitates Pathogenesis to UVB-Induced Cutaneous Inflammation and Basal Cell Carcinoma Development in Ptch+/- Mice

    March 2014 in “ American Journal of Pathology ”
    Jiang Xu, Zhiping Weng, Arunkumar Arumugam … Mohammad Athar
    Studysummary This study found that hairless mice with homozygous mutations developed significantly more aggressive basal cell carcinomas and a heightened inflammatory response to UVB exposure compared to their haired littermates.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on ajp.amjpathol.org →
    Discuss this study in the Community →

    Research cited in this study 9

    1. Cicatricial Alopecia Symposium 2011: Lipids, Inflammation, and Stem Cells Journal of Investigative Dermatology · 2012
    2. Mechanism of JmjC-Containing Protein Hairless in the Regulation of Vitamin D Receptor Function Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 2011
    3. The Pathogenesis of Primary Cicatricial Alopecias The American Journal of Pathology · 2010
    4. Identification of the Cell Lineage at the Origin of Basal Cell Carcinoma Nature Cell Biology · 2010
    5. Genetic Architecture of Mouse Skin Inflammation and Tumor Susceptibility Nature · 2009
    6. Hairless Is a Nuclear Receptor Corepressor Essential for Skin Function Nuclear Receptor Signaling · 2009
    7. Ligand-Independent Regulation of the Hairless Promoter by Vitamin D Receptor Photochemistry and photobiology · 2008
    8. Hedgehog Signaling in Skin Development and Cancer Experimental Dermatology · 2006
    9. The Role of the Hairless (Hr) Gene in the Regulation of Hair Follicle Catagen Transformation American Journal Of Pathology · 1999