Ligand-Independent Regulation of the Hairless Promoter by Vitamin D Receptor

    February 2008 in “ Photochemistry and photobiology ”
    Andrew Engelhard, Robert C. Bauer, Alexandre Casta, Karima Djabali, Angela M. Christiano
    Image of study
    TLDR Vitamin D receptor can control the hairless gene linked to hair loss even without vitamin D.
    The study investigated the relationship between the vitamin D receptor (VDR) and the hairless (hr) gene, both of which are implicated in hair loss disorders such as atrichia and VDRRIIa rickets. The researchers found that VDR can repress the activity of the hr promoter in both HaCaT cells and primary human keratinocytes (PHKs), even in the absence of its ligand, 1,25 dihydroxyvitamin D3 (D3). The repression is enhanced with the addition of D3. Interestingly, they also discovered that VDR can activate the hr promoter without the ligand, but this effect is cell type-specific. These findings suggest that VDR's direct transcriptional regulation of the hr gene may contribute to the similar hair loss phenotypes observed in atrichia and VDRRIIa rickets.
    Discuss this study in the Community →

    Research cited in this study

    17 / 17 results

    Related Community Posts Join

    6 / 1000+ results

      community Why do we get bald from evolutionary perspective

      in Chat  213 upvotes 8 months ago
      Baldness is not an evolutionary disadvantage because it occurs after reproductive age. Treatments like Minoxidil and Finasteride are used for androgenetic alopecia but don't address the root cause.

      community Is Vitamin D the cause of my baldness or slow regrowth?

      in Is this regrowth?  1 upvotes 4 months ago
      The conversation discusses hair loss treatments, including oral finasteride, topical minoxidil, and microneedling, and the potential impact of Vitamin D and folic acid deficiencies on hair regrowth. It suggests that while male pattern baldness is the primary cause, addressing vitamin deficiencies may aid in improving regrowth.

      community Creatine's effect on Hair Loss and DHT

      in Research/Science  100 upvotes 2 years ago
      A 21-year-old male managed to control his hair loss using Nizoral, RU58841, and finasteride, but experienced increased scalp itchiness after starting creatine, which subsided upon stopping creatine. Users shared mixed experiences on whether creatine affects hair loss, with some reporting negative effects and others seeing no change or defending its benefits.

      community Maintaining hair until Breezula without Fin

      in Treatment  6 upvotes 5 years ago
      A 21-year-old male experienced side effects from topical finasteride and is seeking alternative treatments to maintain hair until Breezula is available. He is considering using minoxidil, Nizoral, micro-needling, and vitamin D supplementation, and may try CB or RU58841 if necessary.

    Similar Research

    5 / 1000+ results