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GlossaryGene Expression Regulation (Transcriptional Regulation)

control of when and how much genes produce their products

Gene Expression Regulation refers to the processes that control the timing, location, and amount of a gene's product (such as a protein) being produced. This can involve mechanisms at various stages, including transcription (when DNA is copied into RNA), RNA processing, translation (when RNA is used to make proteins), and post-translational modifications. Proper regulation is crucial for normal development, cellular function, and response to environmental changes.

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research Transcriptional Regulation of the Thymus Master Regulator Foxn1

6 citations, August 2022 in “Science immunology”

Foxn1 gene regulation is crucial for thymus development but not for hair growth.

Post-Transcriptional Regulation of Keratinocyte Progenitor Cell Expansion, Differentiation, and Hair Follicle Regression by miR-22

research Post-Transcriptional Regulation of Keratinocyte Progenitor Cell Expansion, Differentiation, and Hair Follicle Regression by miR-22

52 citations, May 2015 in “PLOS Genetics”

miR-22, a type of microRNA, controls hair growth and its overproduction can cause hair loss, while its absence can speed up hair growth.

research P53-Dependent Transcriptional Regulation of EDA2R and Its Involvement in Chemotherapy-Induced Hair Loss

37 citations, April 2010 in “FEBS Letters”

The study concludes that the EDA2R gene is activated by p53 during chemotherapy but is not necessary for chemotherapy-induced hair loss.

research In-Silico Cardiac Aging Regulatory Model Including MicroRNA Post-Transcriptional Regulation

3 citations, June 2017 in “Methods”

Researchers created a model to understand heart aging, highlighting the role of microRNAs and identifying key genes and pathways involved.

research A Computationally Inferred Regulatory Heart Aging Model Including Post-Transcriptional Regulations

1 citations, December 2016

Researchers created a model to understand heart aging, highlighting key genes and pathways, and suggesting miR-208a as a potential heart attack biomarker.

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community The Real Cause Of Androgenetic Alopecia

in Research/Science 665 upvotes 2 weeks ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community New Research- Creatine Increasing Scalp DHT Without Corresponding Serum DHT Increase

in Research/Science 121 upvotes 5 months ago

Creatine may increase scalp DHT without affecting serum DHT, potentially speeding up male pattern baldness (MPB) for those genetically prone. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community TWIST-1 and the cure: Is it really that easy?

in Research/Science 283 upvotes 2 years ago

TWIST-1 gene's role in hair loss and potential as a treatment target. Inhibiting TWIST-1 may prolong hair growth and reduce hair follicle sensitivity to DHT.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 2 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community 57% increased chance of pattern hair loss independently associated with the consumption of sugary beverages in men (p<0.001) Pt 2

in Research/Science 486 upvotes 3 months ago

Sugary beverages increase the risk of pattern hair loss in men by 57%. Treatments discussed include Minoxidil, finasteride, and RU58841.

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