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GlossaryGene Expression Regulation (Transcriptional Regulation)

control of when and how much genes produce their products

Gene Expression Regulation refers to the processes that control the timing, location, and amount of a gene's product (such as a protein) being produced. This can involve mechanisms at various stages, including transcription (when DNA is copied into RNA), RNA processing, translation (when RNA is used to make proteins), and post-translational modifications. Proper regulation is crucial for normal development, cellular function, and response to environmental changes.

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research New Case of Trichorhinophalangeal Syndrome-Like Phenotype with a De Novo t(2;8)(p16.1;q23.3) Translocation Which Does Not Disrupt the TRPS1 Gene

9 citations , May 2014 in “BMC medical genetics”

A woman with a unique syndrome similar to TRPS has a genetic change near the TRPS1 gene, affecting its regulation.

research To Grow or Not to Grow: Hair Morphogenesis and Human Genetic Hair Disorders

43 citations , December 2013 in “Seminars in Cell & Developmental Biology”

Genetic mutations can cause hair growth disorders by affecting key genes and signaling pathways.

research Differential Expression of KRT83 Regulated by the Transcription Factor CAP1 in Chinese Tan Sheep

5 citations , March 2017 in “Gene”

CAP1 decreases the expression of a hair-related protein in young Tan sheep's skin.

research MitoQ Enhances CYP19A1 Expression to Stimulate WNT/β-Catenin Signaling Pathway for Promoting Hair Growth in Androgenetic Alopecia

November 2024 in “European Journal of Pharmacology”

MitoQ may help treat hair loss by boosting hair growth pathways.

research Probing Keratinocyte and Differentiation Specificity of the Human K5 Promoter In Vitro and In Transgenic Mice

133 citations , June 1993 in “Molecular and Cellular Biology”

The human K5 promoter controls specific gene expression in skin cells, with key regulatory elements near the TATA box.

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community The Real Cause Of Androgenetic Alopecia

in Research/Science 673 upvotes 1 year ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community Minoxidil Response Bottlenecks: Why Sulfation and Transport Matter (And Where Tretinoin Fits In)

nkrata in Research 461 upvotes 9 months ago

Minoxidil's effectiveness is limited by the need for sulfation and proper transport to hair follicles, with tretinoin potentially enhancing its effects by promoting enzyme activity and keratinocyte differentiation. Tretinoin may improve minoxidil's response by boosting the expression of necessary enzymes and transporters.

community JXL082 is not PP405 and Everychem followed the wrong lead

in Research/Science 42 upvotes 7 months ago

JXL082 is not the same as PP405, leading to a halt in sales and a plan to synthesize the real PP405. There is skepticism about the safety and effectiveness of JXL082 and PP405, with concerns about patent issues and the long-term impact on hair growth.

community New Research- Creatine Increasing Scalp DHT Without Corresponding Serum DHT Increase

in Research/Science 124 upvotes 1 year ago

Creatine may increase scalp DHT without affecting serum DHT, potentially speeding up male pattern baldness (MPB) for those genetically prone. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community My Testosterone results before and after Finasteride

in Update 145 upvotes 4 years ago

Finasteride significantly increased testosterone levels for the user, with no major side effects except watery semen, which was resolved with zinc supplements. The user's hairline stopped receding and slightly improved.

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