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GlossaryEpigenetics

study of how gene activity is regulated without changing DNA sequence

Epigenetics refers to the study of changes in gene expression that do not involve alterations to the underlying DNA sequence. These changes can be influenced by various factors such as environment, lifestyle, and disease, and they can affect how cells read genes, potentially leading to conditions like alopecia.

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research States and Fates of Skin Fibroblasts Revealed Through Chromatin Accessibility

February 2022 in “Journal of Investigative Dermatology”

Newborn skin cells can change into wound-healing cells more easily than adult ones, which might explain why baby skin heals without scars. Understanding this could help treat chronic wounds and prevent scarring.

research How a Bird Gets Its Feathers: Insights from Chromatin Looping

3 citations, June 2020 in “Developmental Cell”

Feather patterns are influenced by enhancers and chromatin looping, and the structure of protein complexes important for hair growth has been detailed.

research Epigenetic Effects of Finasteride on Dopaminergic Signaling Pathways: A Potential Contributor to Post-Finasteride Syndrome

May 2024 in “Physiology”

Finasteride may cause changes in dopamine-related genes, possibly leading to post-finasteride syndrome.

Therapeutic Hotline: Genetic Variations in the Androgen Receptor Gene and Finasteride Response in Women with Androgenetic Alopecia Mediated by Epigenetics

research Therapeutic Hotline: Genetic Variations in the Androgen Receptor Gene and Finasteride Response in Women with Androgenetic Alopecia Mediated by Epigenetics

16 citations, March 2011 in “Dermatologic Therapy”

Women with greater androgen sensitivity respond better to finasteride for hair loss.

research Alopecia Areata: Animal Models

69 citations, July 2002 in “Clinical and Experimental Dermatology”

Alopecia areata is influenced by genetics and immune system factors, and better understanding could improve treatments.

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community Interesting article links major MPB theories to western diet (and life-style)

in Research/Science 58 upvotes 3 months ago

Poor diet and lifestyle contribute to male pattern baldness. Treatments like Minoxidil, dietary changes, and lifestyle adjustments may help slow hair loss.

community So we have 20k dollars human like machines available but no new effective treatment for hairloss since finasteride :)

in Chat 237 upvotes 4 months ago

There have been no new effective hair loss treatments since finasteride, despite technological advancements. Current treatments include finasteride, minoxidil, and RU58841, with ongoing challenges and potential future solutions in research.

community abusing caffeine boosts DHT levels!

in Research/Science 1 upvotes 4 months ago

Caffeine intake may increase DHT levels, but its impact on hair loss is minimal compared to genetic factors. Excessive caffeine can cause health issues, and its effects on hair loss are not directly applicable to humans based on rat studies.

community My hair after 3 steroid cycles

in Progress Pictures 24 upvotes 7 months ago

A user shared their hair progress after three steroid cycles, using 5% minoxidil and 100mg RU58841 daily. They are considering a hair transplant due to paranoia about shedding.

community Had a son while being on FIN, MUST READ

in Finasteride/Dutasteride 619 upvotes 1 year ago

A user shared his experience of having two healthy children while continuously using finasteride (Fin) for hair loss, challenging fears about its potential impact on fetal development. The discussion that followed included various perspectives, with some users sharing similar experiences, others expressing concerns about potential risks, and some emphasizing the need for more substantial evidence before drawing conclusions.

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