Evidence for 1,25-Dihydroxyvitamin D3-Independent Transactivation by the Vitamin D Receptor

    February 2007 in “ Journal of biological chemistry/˜The œJournal of biological chemistry ”
    Tara I. Ellison, Richard L. Eckert, Paul N. MacDonald
    Studysummary This study found that vitamin D receptor activation in primary keratinocytes can occur independently of the 1,25-dihydroxyvitamin D<sub>3</sub> ligand, likely through interaction with retinoid X receptors.
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    Research cited in this study 7

    1. Ligand-Independent Actions of the Vitamin D Receptor Maintain Hair Follicle Homeostasis Molecular Endocrinology · 2004
    2. 25 Hydroxyvitamin D 1 Alpha-Hydroxylase Is Required for Optimal Epidermal Differentiation and Permeability Barrier Homeostasis ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2004
    3. Vitamin D: More Than a Bona Fide Hormone Molecular endocrinology · 2003
    4. Deletion of DNA Binding Domain of the Vitamin D Receptor Abrogates Genomic and Nongenomic Functions of Vitamin D Molecular Endocrinology · 2002
    5. Targeting Expression of the Human Vitamin D Receptor to the Keratinocytes of Vitamin D Receptor Null Mice Prevents Alopecia Endocrinology · 2001
    6. Metabolic And Cellular Analysis Of Alopecia In Vitamin D Receptor Knockout Mice Journal of Clinical Investigation · 2001
    7. Normalization of Mineral Ion Homeostasis by Dietary Means Prevents Hyperparathyroidism, Rickets, and Osteomalacia, But Not Alopecia in Vitamin D Receptor-Ablated Mice Endocrinology · 1998