TLDR The vitamin D receptor can work without its usual activating molecule.
The study provided evidence that the Vitamin D Receptor (VDR) could activate transcription independently of its ligand, 1,25-Dihydroxyvitamin D3 (1,25(OH)2D3), specifically in primary keratinocytes. This was demonstrated by the activation of the 24-hydroxylase promoter without 1,25(OH)2D3. The findings suggested that VDR might interact with other ligands or undergo modifications such as phosphorylation to exert its effects. This ligand-independent activity was unique to keratinocytes and selective for certain promoters, indicating a potential for targeted therapeutic strategies in skin disorders like psoriasis and skin cancer without causing hypercalcemia. The study also highlighted the importance of VDR-RXR heterodimerization in this process.
140 citations,
April 2004 in “The journal of investigative dermatology/Journal of investigative dermatology” The enzyme 25 Hydroxyvitamin D 1 α-Hydroxylase is essential for healthy skin and recovery after skin damage.
276 citations,
April 2003 in “Molecular endocrinology” Vitamin D is important for bones, hair, blood pressure, and breast development.
277 citations,
July 2002 in “Molecular Endocrinology” Removing part of the vitamin D receptor stops vitamin D from working properly.
25 citations,
August 2014 in “Endocrinology” Researchers created a mouse model of a type of rickets that does not cause hair loss.
104 citations,
May 2003 in “Endocrinology” Lampreys have a functional vitamin D receptor that may help detoxify harmful substances.
62 citations,
January 2009 in “Biochemistry” Vitamin D receptor binds similarly to natural and synthetic ligands, affecting gene regulation.
1533 citations,
October 2008 in “Endocrine reviews” Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.
1308 citations,
March 1998 in “Journal of bone and mineral research” The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.
139 citations,
February 2014 in “Journal of Advanced Research” Vitamin D is important for skin health and may affect conditions like psoriasis and hair loss, but more research is needed to understand its role fully.
