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research 1,25-(OH)2D3 promotes hair growth by inhibiting NLRP3/IL-1β and HIF-1α/IL-1β signaling pathways

June 2024 in “The Journal of Nutritional Biochemistry”

This study found that 1,25-dihydroxyvitamin D3 promotes hair growth and regeneration in mice by prolonging the anagen phase and counteracting DHT's inhibitory effects, suggesting its potential therapeutic role for androgenetic alopecia.

research In vivo microautoradiography of [3H]1,24(OH)2D3 (tacalcitol) following topical application to normal rats and in vitro metabolism in human keratinocytes

7 citations , April 1996 in “Archives of dermatological research”

This study found that after topical application in rats, 1,24-dihydroxyvitamin D3 absorbed through both the stratum corneum and hair follicles, with about 30% excreted via the faeces.

research Hereditary 1,25‐Dihydroxyvitamin D–Resistant Rickets Due to an Opal Mutation Causing Premature Termination of the Vitamin D Receptor

47 citations , February 1998 in “Journal of bone and mineral research”

In this study, researchers identified a unique Arg30stop mutation in the vitamin D receptor gene that causes hereditary vitamin D-resistant rickets in a young French-Canadian boy by truncating the receptor and causing hormone resistance.

research The vitamin D receptor functions as a transcription regulator in the absence of 1,25-dihydroxyvitamin D3

37 citations , August 2015 in “The Journal of Steroid Biochemistry and Molecular Biology”

This study found that in a mouse model with hereditary 1,25-dihydroxyvitamin D resistant rickets, a mutant vitamin D receptor lacking hormone-binding ability could restore normal hair cycling and affect parathyroid hormone regulation.

research Two New Unrelated Cases of Hereditary 1,25-Dihydroxyvitamin D-resistant Rickets with Alopecia resulting from the same Novel Nonsense Mutation in the Vitamin D Receptor Gene

36 citations , January 2010 in “Journal of Pediatric Endocrinology and Metabolism”

This study identified a novel nonsense mutation in the VDR gene in two patients with hereditary vitamin D resistant rickets and alopecia, leading to resistance to 1,25-dihydroxyvitamin D3.

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community Finally live! alcohol-free, propylene glycol–free topical finasteride foam

17 upvotes 10 months ago

A new alcohol-free, propylene glycol-free topical finasteride foam is available for prescription in Canada and the USA, offering a cleaner alternative for hair loss treatment. The product also offers a combination of 0.1% finasteride with 5% minoxidil and aims to be affordable and less irritating for sensitive scalps.

community 0.5mg Dutasteride promotes more “regrowth” than 5mg oral Minoxidil

in Research/Science 117 upvotes 2 years ago

Dutasteride promotes more hair regrowth than Minoxidil. Users discuss combining treatments for better results and share personal experiences with side effects.

community 1 year 1 month 1mg finasteride 2.5mg oral minoxidil (eyebrow + scalp gains)

in Progress Pictures 178 upvotes 1 year ago

The conversation is about a user's positive experience with hair regrowth using 1mg finasteride and 2.5mg oral minoxidil, noting improvements in scalp and eyebrow hair. The user mentions minimal side effects, such as a slight increase in heart rate, and prefers oral minoxidil over topical due to ease of use.

community 1 year vs 2 years on 1mg Finasteride [29M]

in Progress Pictures 16 upvotes 7 months ago

The user has been on 1mg finasteride daily for two years, experiencing initial shedding and some hairline recession, with limited regrowth. Suggestions include using oral minoxidil, switching to dutasteride, or considering a hair transplant for better results.

community 1 Year Finasteride + 2.5 Oral Minoxidil

in Progress Pictures 606 upvotes 1 year ago

Significant hair regrowth was achieved using finasteride and 2.5mg oral minoxidil over a year, despite initial shedding. The treatment is recommended, though it may cause increased heart rate and body hair growth.

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