1,25-(OH)2D3 Promotes Hair Growth by Inhibiting NLRP3/IL-1β and HIF-1α/IL-1β Signaling Pathways

June 2024 in “ The Journal of Nutritional Biochemistry ”

Xiule Zong, Shengbo Yang, Ziting Tang, Xuemei Li, Dahong Long, Dan Wang

1,25-(OH)2D3 NLRP3 IL-1β HIF-1α hair follicle anagen phase dermal papilla cells outer root sheath keratinocytes VDR DHT androgenetic alopecia AGA Vitamin D3 hair growth phase hair follicle cells Vitamin D receptor dihydrotestosterone male pattern baldness

Studysummary This study found that 1,25-dihydroxyvitamin D3 promotes hair growth and regeneration in mice by prolonging the anagen phase and counteracting DHT's inhibitory effects, suggesting its potential therapeutic role for androgenetic alopecia. Our plain-language summary of this paper — not a Tressless recommendation.

The study demonstrates that 1,25-(OH)2D3, the active form of Vitamin D, promotes hair growth in mice by acting through the Vitamin D Receptor (VDR). It prolongs the anagen phase of hair follicles and enhances the proliferation and migration of dermal papilla cells and outer root sheath keratinocytes. The research identifies NLRP3-IL-1β and HIF-1α-IL-1β as key downstream molecules in this pathway. Additionally, 1,25-(OH)2D3 shows potential as a therapeutic agent for treating androgenetic alopecia (AGA).

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Adipose-Derived Stem Cell Exosomes Antagonize the Inhibitory Effect of Dihydrotestosterone on Hair Follicle Growth by Activating Wnt/Beta-Catenin Pathway

research Adipose-Derived Stem Cell Exosomes Antagonize the Inhibitory Effect of Dihydrotestosterone on Hair Follicle Growth by Activating Wnt/Beta-Catenin Pathway

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This study using human and animal models found that adipose-derived stem cell exosomes promoted hair growth and counteracted dihydrotestosterone's inhibitory effects, suggesting potential therapeutic applications for androgenetic alopecia.

research VDR Is an Essential Regulator of Hair Follicle Regression Through the Progression of Cell Death

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This study found that exosomes derived from dermal papilla cells can enhance the proliferation of hair follicle stem cells by stimulating the LEF1 pathway, offering insights into hair follicle growth regulation.

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In this study, researchers identified key transcriptome changes in male androgenetic alopecia hair follicles, suggesting that HIF-1 pathway genes and Wnt pathway inhibitors could be potential therapeutic targets.

Transcriptome Analysis Reveals an Inhibitory Effect of Dihydrotestosterone-Treated 2D- and 3D-Cultured Dermal Papilla Cells on Hair Follicle Growth

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