1,25-(OH)2D3 Promotes Hair Growth by Inhibiting NLRP3/IL-1β and HIF-1α/IL-1β Signaling Pathways

    Xiule Zong, Shengbo Yang, Ziting Tang, Xuemei Li, Dahong Long, Dan Wang
    TLDR 1,25-(OH)2D3 helps hair grow by blocking certain harmful signals.
    The study demonstrates that 1,25-(OH)2D3, the active form of Vitamin D, promotes hair growth in mice by acting through the Vitamin D Receptor (VDR). It prolongs the anagen phase of hair follicles and enhances the proliferation and migration of dermal papilla cells and outer root sheath keratinocytes. The research identifies NLRP3-IL-1β and HIF-1α-IL-1β as key downstream molecules in this pathway. Additionally, 1,25-(OH)2D3 shows potential as a therapeutic agent for treating androgenetic alopecia (AGA).
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