1,25-(OH)2D3 Promotes Hair Growth by Inhibiting NLRP3/IL-1β and HIF-1α/IL-1β Signaling Pathways

    Xiule Zong, Shengbo Yang, Ziting Tang, Xuemei Li, Dahong Long, Dan Wang
    TLDR 1,25-(OH)2D3 helps hair grow by blocking certain harmful signals.
    The study demonstrates that 1,25-(OH)2D3 promotes hair growth in mice by inhibiting the NLRP3/IL-1β and HIF-1α/IL-1β signaling pathways. Through in vivo experiments, in vitro organ culture, and cellular-level investigations, it was found that 1,25-(OH)2D3 enhances hair follicle anagen phase, and increases the proliferation and migration of dermal papilla cells and outer root sheath keratinocytes in a VDR-dependent manner. Transcriptome analysis of VDR-knockout mouse skin highlighted the involvement of HIF-1α, NLRP3, and IL-1β. Additionally, 1,25-(OH)2D3 counteracts the inhibitory effects of DHT on hair growth, suggesting its potential as a therapeutic agent for androgenetic alopecia (AGA).
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