Vitamin D and Calcium Signaling in Epidermal Stem Cells and Their Regeneration

July 2020 in “ World journal of stem cells ”

Yuko Oda, Daniel D. Bikle

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Studysummary This review discusses vitamin D and calcium signaling roles in epidermal stem cell processes essential for wound healing but reports no new experimental results, emphasizing their potential interdependent regulatory mechanisms.

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The document from July 26, 2020, investigated the role of Vitamin D and calcium in the functioning and regeneration of epidermal stem cells, particularly in the context of wound healing. The study found that Vitamin D and calcium signaling are crucial for the maintenance, differentiation, and self-renewal of these cells, which are essential for skin homeostasis, hair follicle regeneration, and wound re-epithelialization. These processes are mediated through β-catenin and E-cadherin mediated adherens junction signaling. The study also found that Vitamin D receptor (Vdr) conditional knockout (cKO) mouse skin experienced a delay in wound re-epithelialization under low dietary calcium conditions, suggesting a cooperative role of Vdr with calcium signaling in the epidermis. The document concluded that Vitamin D and calcium signaling regulate injury induced epidermal regeneration mutually and interdependently, and understanding this could lead to better therapies for skin diseases, hair loss, and chronic wounds.

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Vitamin D Receptor Is Required for Proliferation, Migration, and Differentiation of Epidermal Stem Cells and Progeny During Cutaneous Wound Repair

research Vitamin D Receptor Is Required for Proliferation, Migration, and Differentiation of Epidermal Stem Cells and Progeny During Cutaneous Wound Repair

46 citations , May 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that the vitamin D receptor is essential for the self-renewal, migration, and differentiation of epidermal stem cells during skin wound healing in mice.

research Combined Deletion of the Vitamin D Receptor and Calcium-Sensing Receptor Delays Wound Re-Epithelialization

28 citations , March 2017 in “Endocrinology”

In this study, the researchers found that vitamin D and calcium signaling in keratinocytes are essential for normal skin regeneration after wounding, with deficiencies significantly delaying wound closure and re-epithelialization in mice.

research Vitamin D And Calcium Regulation Of Epidermal Wound Healing

86 citations , August 2015 in “The Journal of Steroid Biochemistry and Molecular Biology”

This study suggests that vitamin D and calcium signaling play a crucial role in wound healing by regulating stem cell activation through enhanced β-catenin transcriptional activity in mice.

research The Vitamin D Receptor Is Required for Activation of CWnt and Hedgehog Signaling in Keratinocytes

56 citations , September 2014 in “Molecular Endocrinology”

This study found that the absence of unliganded vitamin D receptor significantly impairs cWnt and hedgehog signaling pathways necessary for hair cycle initiation in VDR-null mice.

research In Vivo Transcriptional Governance of Hair Follicle Stem Cells by Canonical Wnt Regulators

173 citations , January 2014 in “Nature Cell Biology”

This study found that Wnt signalling activates hair follicle fate in hair follicle stem cells by relieving TCF3/4–TLE-mediated repression, with β-catenin being crucial for this process.

research Ligand-Dependent Actions of the Vitamin D Receptor Are Required for Activation of TGF-Beta Signaling During the Inflammatory Response to Cutaneous Injury

56 citations , November 2012 in “Endocrinology”

This study found that the absence of vitamin D receptor signaling in mice impairs the inflammatory response to skin injury, particularly affecting macrophage recruitment and granulation tissue formation.

research Epithelial Stem Cells And Implications For Wound Repair

156 citations , October 2012 in “Seminars in Cell & Developmental Biology”

This study found that hair follicle stem cells initially contribute to wound re-epithelialization, but long-lasting epidermal cells are primarily derived from a stem cell population in the isthmus portion of hair follicles.

research Vitamin D Metabolism and Function in the Skin

185 citations , June 2011 in “Molecular and cellular endocrinology”

This review discusses the regulation and function of vitamin D and its receptor in skin cells, highlighting their roles in processes such as proliferation inhibition, differentiation, and innate immunity, but reports no new results.

research Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis

503 citations , May 2009 in “Cell stem cell”

This study suggests that Lrig1-positive cells form a previously unknown reservoir of interfollicular epidermal stem cells in adult mouse skin, influencing epidermal proliferation and hair follicle development.

research The Vitamin D Receptor Is a Wnt Effector That Controls Hair Follicle Differentiation and Specifies Tumor Type in Adult Epidermis

127 citations , January 2008 in “PloS one”

This study observed that the vitamin D receptor is crucial for hair follicle formation and altering tumor development in the Wnt signaling pathway, suggesting therapeutic potential for vitamin D analogues in related tumors.