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GlossaryNLRP3

protein involved in immune response and inflammation regulation

NLRP3 is a protein that plays a crucial role in the body's immune response. It is part of a larger complex called the inflammasome, which helps detect harmful substances and triggers inflammation to fight off infections. In some cases, overactivation of NLRP3 can lead to chronic inflammatory diseases.

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Hair Follicle Mesenchymal Stem Cell Exosomal LncRNA H19 Inhibited NLRP3 Pyroptosis to Promote Diabetic Mouse Skin Wound Healing

research Hair Follicle Mesenchymal Stem Cell Exosomal LncRNA H19 Inhibited NLRP3 Pyroptosis to Promote Diabetic Mouse Skin Wound Healing

13 citations , February 2023 in “Aging”

A substance from hair follicle stem cells helps heal skin wounds in diabetic mice by promoting cell growth and preventing cell death.

research Total glucosides of paeony inhibit NLRP3/caspase-1/GSDMD-mediated inflammation and pyroptosis in C3H/HeJ mice with alopecia areata

5 citations , September 2024 in “Biomolecules and Biomedicine”

Total glucosides of paeony may help treat alopecia areata by reducing inflammation and hair loss.

Melatonin Alleviates Oxygen-Glucose Deprivation/Reperfusion-Induced Pyroptosis of HEI-OC1 Cells and Cochlear Hair Cells via MT-1,2/Nrf2/ROS/NLRP3 Pathway

research Melatonin Alleviates Oxygen-Glucose Deprivation/Reperfusion-Induced Pyroptosis of HEI-OC1 Cells and Cochlear Hair Cells via MT-1,2/Nrf2/ROS/NLRP3 Pathway

5 citations , November 2022 in “Molecular Neurobiology”

Melatonin may protect inner ear cells from damage by reducing cell death and oxidative stress, potentially treating sudden hearing loss.

research 1,25-(OH)2D3 Promotes Hair Growth by Inhibiting NLRP3/IL-1β and HIF-1α/IL-1β Signaling Pathways

June 2024 in “The Journal of Nutritional Biochemistry”

1,25-(OH)2D3 helps hair grow by blocking certain harmful signals.

PX-12 Inhibits NLRP3 Inflammasome Activation to Treat Psoriasis

research PX-12 Inhibits NLRP3 Inflammasome Activation to Treat Psoriasis

April 2023 in “Journal of Investigative Dermatology”

PX-12 may help treat psoriasis by blocking inflammation and cell death.

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