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GlossaryNLRP3 inflammasome

protein complex triggering inflammation in response to cellular stress

The NLRP3 inflammasome is a protein complex within cells that plays a crucial role in the body's immune response. It detects harmful stimuli, such as infections or cellular damage, and activates inflammatory processes to help fight off these threats. This complex is significant in various diseases, including autoimmune disorders and conditions like alopecia, where inflammation can affect hair follicles.

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research Hair Follicle Mesenchymal Stem Cell Exosomal LncRNA H19 Inhibited NLRP3 Pyroptosis to Promote Diabetic Mouse Skin Wound Healing

13 citations , February 2023 in “Aging”

A substance from hair follicle stem cells helps heal skin wounds in diabetic mice by promoting cell growth and preventing cell death.

research PX-12 Inhibits NLRP3 Inflammasome Activation to Treat Psoriasis

April 2023 in “Journal of Investigative Dermatology”

PX-12 may help treat psoriasis by blocking inflammation and cell death.

research Acne-Associated Syndromes

January 2019 in “Springer eBooks”

Acne is linked to inflammation and insulin resistance, and is associated with various syndromes that require different treatments.

The Possible Role of PTEN-Induced Kinase 1-Mediated Mitophagy in Regulating Inflammasome Activation in the Pathogenesis of Alopecia Areata

research The Possible Role of PTEN-Induced Kinase 1-Mediated Mitophagy in Regulating Inflammasome Activation in the Pathogenesis of Alopecia Areata

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Activating mitophagy may help manage a key immune response involved in the hair loss condition alopecia areata.

research Fermented Yeast Complex Extract Promotes Hair Regrowth by Decreasing Oxidative Stress

December 2025 in “Antioxidants”

Fermented Yeast Complex Extract helps regrow hair by reducing oxidative stress and inflammation.

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