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GlossaryNLRP1 Inflammasome

protein complex triggering inflammation in response to cellular stress

The NLRP1 inflammasome is a protein complex in the body's immune system that detects harmful pathogens and stress signals. When activated, it triggers an inflammatory response to help fight infections and repair tissue damage. This process is crucial for maintaining health, but if it becomes overactive, it can contribute to inflammatory diseases.

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research NLRP1 Promotes Tumor Growth by Enhancing Inflammasome Activation and Suppressing Caspase-3 Activity in Human Melanoma

1 citations, April 2016 in “Journal of Investigative Dermatology”

NLRP1 helps melanoma tumors grow by boosting inflammasome activation and reducing caspase-3 activity.

research Inflammasome Proteins as Biomarkers of Injury and Disease

January 2014 in “Springer eBooks”

Inflammasome proteins can indicate the severity and treatment response of various diseases and injuries.

research Uncovering the Role of UV Exposure History and Genetics in Determining Skin Sun Damage

1 citations, April 2016 in “Journal of Investigative Dermatology”

UV photography can help identify people at higher risk for skin cancer, and male pattern baldness at age 45 is linked to a higher risk of certain skin cancers.

research SOX4 Is Essential for Melanoma Tumorigenesis

April 2016 in “Journal of Investigative Dermatology”

SOX4 is crucial for the development of melanoma.

research Aberrant Inflammasome Activation as a Driving Force of Human Autoimmune Skin Disease

3 citations, May 2023 in “Frontiers in immunology”

Faulty inflammasome activation may lead to autoimmune skin diseases and could be a target for new treatments.

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