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    Glossary NLRP1 Inflammasome

    protein complex triggering inflammation in response to cellular stress

    The NLRP1 inflammasome is a protein complex in the body's immune system that detects harmful pathogens and stress signals. When activated, it triggers an inflammatory response to help fight infections and repair tissue damage. This process is crucial for maintaining health, but if it becomes overactive, it can contribute to inflammatory diseases.

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    Research 30 of 531

    1. Spatiotemporal regulation of acute wound healing by the NLRP3 inflammasome: dual roles in macrophage-fibroblast chemotaxis and phenotype during wound repair Burns & Trauma · 2026
    2. 1117 PX-12 inhibits NLRP3 inflammasome activation to treat psoriasis Journal of Investigative Dermatology · 2023
    3. 647 NLRP1 promotes tumor growth by enhancing inflammasome activation and suppressing caspase-3 activity in human melanoma Journal of Investigative Dermatology · 2016 · 1 citations
    4. Advancements in research on the immune-inflammatory mechanisms mediated by NLRP3 inflammasome in ischemic stroke and the regulatory role of natural plant products Frontiers in Pharmacology · 2024 · 18 citations
    5. NFAT5 mediates hypertonic stress-induced atherosclerosis via activating NLRP3 inflammasome in endothelium Cell Communication and Signaling · 2019 · 50 citations
    6. Aberrant inflammasome activation as a driving force of human autoimmune skin disease Frontiers in immunology · 2023 · 3 citations
    7. Double-stranded RNA induces inflammation via the NF-κB pathway and inflammasome activation in the outer root sheath cells of hair follicles Scientific reports · 2017 · 22 citations
    8. Hair follicle mesenchymal stem cell exosomal lncRNA H19 inhibited NLRP3 pyroptosis to promote diabetic mouse skin wound healing Aging · 2023 · 13 citations
    9. Protective role of agomelatine via modulation of TLR4/NF-κB: NLRP3/IL-1β signaling pathways in testosterone-induced benign prostatic hyperplasia in rats Naunyn-Schmiedeberg s Archives of Pharmacology · 2025
    10. 1330 The possible role of PTEN-induced kinase 1-mediated mitophagy by regulating inflammasome activation in the pathogenesis of alopecia areata 2023
    11. Baricitinib Attenuates IFN-γ and Polyinosinic:polycytidylic Acid‒Induced Mitochondrial Damage and Inflammasome Activation in Human Keratinocytes Journal of Investigative Dermatology · 2022
    12. Inflammasome Proteins as Biomarkers of Injury and Disease Springer eBooks · 2014
    13. Fermented Yeast Complex Extract Promotes Hair Regrowth by Decreasing Oxidative Stress Antioxidants · 2025
    14. Acne-Associated Syndromes Springer eBooks · 2019
    15. The role of skin macrophages under conditions of stress and injury: ultraviolet irradiation and wound healing 2018
    16. 642 Uncovering the role of UV exposure history and genetics in determining skin sun damage Journal of Investigative Dermatology · 2016 · 1 citations
    17. 646 SOX4 is essential for melanoma tumorigenesis Journal of Investigative Dermatology · 2016
    18. Smart Fluids As Autophagy-Activating Photoprotectors: In Vitro Analysis of Dead Sea Water and Magnetized Saline Water Against Ultraviolet B (UVB)-Induced Photodamage in Human Keratinocytes Cureus · 2025 · 1 citations
    19. The crosstalk between PTEN ‐induced kinase 1‐mediated mitophagy and the inflammasome in the pathogenesis of alopecia areata Experimental Dermatology · 2023 · 6 citations
    20. Revealing biological mechanisms of skin pigment recovery during treatment in vitiligo patients: A proteomic analysis Journal of Investigative Dermatology · 2026
    21. Matrix remodelling and MMP expression/activation are associated with hidradenitis suppurativa skin inflammation Experimental Dermatology · 2019 · 51 citations
    22. Evidence on Hidradenitis Suppurativa as an Autoinflammatory Skin Disease Journal of Clinical Medicine · 2024 · 9 citations
    23. Therapeutic Effects of Alkaloids on Influenza: A Systematic Review and Meta-Analysis of Preclinical Studies International Journal of Molecular Sciences · 2025
    24. Melatonin Alleviates the Oxygen–Glucose Deprivation/Reperfusion-Induced Pyroptosis of HEI-OC1 Cells and Cochlear Hair Cells via MT-1,2/Nrf2 (NFE2L2)/ROS/NLRP3 Pathway Molecular Neurobiology · 2022 · 5 citations
    25. Inflammasome Proteins Are Reliable Biomarkers of the Inflammatory Response in Aneurysmal Subarachnoid Hemorrhage Cells · 2024 · 4 citations
    26. Proof-of-Principle Study of Inflammasome Signaling Proteins as Diagnostic Biomarkers of the Inflammatory Response in Parkinson’s Disease Pharmaceuticals · 2023 · 17 citations
    27. Umbilical cord mesenchymal stem cell-derived apoptotic extracellular vesicles ameliorate cutaneous wound healing in type 2 diabetic mice via macrophage pyroptosis inhibition Stem cell research & therapy · 2023 · 4 citations
    28. Hidradenitis Suppurativa as a Potential Subtype of Autoinflammatory Keratinization Disease Frontiers in immunology · 2020 · 41 citations
    29. Inflammation in androgenetic alopecia and hair loss: linking neurosciences-endocrinology-dermatology Hair transplant forum international · 2012 · 1 citations
    30. Pyroptosis in Alopecia Areata: Synthesizing Emerging Hypotheses and Charting a Path to New Therapies Biomedicines · 2025