Insights Into Male Androgenetic Alopecia Using Comparative Transcriptome Profiling: Hypoxia-Inducible Factor-1 and Wnt/Beta-Catenin Signalling Pathways

    July 2022 in “ British Journal of Dermatology ”
    Qing-Mei Liu, Yulong Tang, Yan Huang … Wenyu Wu
    Studysummary In this study, researchers identified key transcriptome changes in male androgenetic alopecia hair follicles, suggesting that HIF-1 pathway genes and Wnt pathway inhibitors could be potential therapeutic targets.
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    Research cited in this study 31

    1. Increased Expression of Zyxin and Its Potential Function in Androgenetic Alopecia Frontiers in Cell and Developmental Biology · 2021
    2. MiRNA Microarray Profiling in Patients with Androgenic Alopecia and the Effects of miR-133b on Hair Growth Experimental and Molecular Pathology · 2020
    3. Defining MicroRNA Signatures of Hair Follicular Stem and Progenitor Cells in Healthy and Androgenic Alopecia Patients Journal of Dermatological Science · 2020
    4. LncRNA H19 Overexpression Activates Wnt Signaling to Maintain the Hair Follicle Regeneration Potential of Dermal Papilla Cells Frontiers in Genetics · 2020
    5. Culture and Differentiation of Human Hair Follicle Dermal Papilla Cells in a Soft 3D Self-Assembling Peptide Scaffold Biomolecules · 2020
    6. Medical Education and Care in Dermatology During the SARS-CoV-2 Pandemic: Challenges and Opportunities Journal of the European Academy of Dermatology and Venereology · 2020
    7. A Combination of Pyridine-2, 4-Dicarboxylic Acid Diethyl Ester and Resveratrol Stabilizes Hypoxia-Inducible Factor 1-Alpha and Improves Hair Density in Female Volunteers International Journal of Cosmetic Science · 2020
    8. MiR-218-5p Regulates Skin and Hair Follicle Development Through Wnt/β-Catenin Signaling Pathway by Targeting SFRP2 Journal of cellular physiology · 2019
    9. Dickkopf-1 Expression in Androgenetic Alopecia and Alopecia Areata in Male Patients American Journal of Dermatopathology · 2019
    10. Secreted Frizzled-Related Protein 4 Inhibits the Regeneration of Hair Follicles PeerJ · 2019
    11. Quality of Life Assessment in Patients with Androgenetic Alopecia International Journal of Trichology · 2019
    12. Insights into Male Androgenetic Alopecia: Differential Gene Expression Profiling of Plucked Hair Follicles and Integration with Genetic Data Journal of Investigative Dermatology · 2018
    13. Identifying Novel Strategies for Treating Human Hair Loss Disorders: Cyclosporine A Suppresses the Wnt Inhibitor, SFRP1, in the Dermal Papilla of Human Scalp Hair Follicles PLOS Biology · 2018
    14. Androgen Modulation of Wnt/β-Catenin Signaling in Androgenetic Alopecia Archives of Dermatological Research · 2018
    15. Minoxidil Induction of VEGF Is Mediated by Inhibition of HIF-Prolyl Hydroxylase International Journal of Molecular Sciences · 2017
    16. Meta-Analysis Identifies Novel Risk Loci and Yields Systematic Insights into the Biology of Male-Pattern Baldness Nature communications · 2017
    17. Classification of Male-Pattern Hair Loss International Journal of Trichology · 2017
    18. Androgens Modify Wnt Agonists/Antagonists Expression Balance in Dermal Papilla Cells Preventing Hair Follicle Stem Cell Differentiation in Androgenetic Alopecia Molecular and Cellular Endocrinology · 2016
    19. Androgenetic Alopecia: An Update Of Treatment Options Drugs · 2016
    20. Differential Expression Between Human Dermal Papilla Cells from Balding and Non-Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia Journal of Investigative Dermatology · 2016
    21. SFRP2 Augments Wnt/β-Catenin Signalling in Cultured Dermal Papilla Cells Experimental Dermatology · 2016
    22. A Guide to Studying Human Hair Follicle Cycling In Vivo Journal of Investigative Dermatology · 2015
    23. Does Prostaglandin D2 Hold the Cure to Male Pattern Baldness? Experimental Dermatology · 2014
    24. Expression Of Sfrp2 Is Increased In Catagen Of Hair Follicles And Inhibits Keratinocyte Proliferation Annals of Dermatology · 2014
    25. Tuning Wnt Signals for More or Fewer Hairs Journal of Investigative Dermatology · 2013
    26. Hair Follicle Stem Cell Differentiation Is Inhibited Through Cross-Talk Between Wnt/β-Catenin and Androgen Signaling in Dermal Papilla Cells From Patients With Androgenetic Alopecia British Journal of Dermatology · 2012
    27. Differential Expression Analysis of Balding and Nonbalding Dermal Papilla MicroRNAs in Male Pattern Baldness Using a MicroRNA Amplification Profiling Method British Journal of Dermatology · 2011
    28. MicroRNAs Take Part in Pathophysiology and Pathogenesis of Male Pattern Baldness Molecular Biology Reports · 2009
    29. Human Hair Growth Ex Vivo Is Correlated With In Vivo Hair Growth: Selective Categorization of Hair Follicles for More Reliable Hair Follicle Organ Culture Archives of Dermatological Research · 2005
    30. Androgenetic Alopecia: Pathogenesis and Potential for Therapy Expert Reviews in Molecular Medicine · 2002
    31. Loss of Vascular Endothelial Growth Factor in Human Alopecia Hair Follicles Journal of Investigative Dermatology · 1995

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