Insights Into Male Androgenetic Alopecia Using Comparative Transcriptome Profiling: Hypoxia-Inducible Factor-1 and Wnt/Beta-Catenin Signalling Pathways

    Qing-Mei Liu, Yulong Tang, Yan Huang, Jing Wang, Kai Yang, Yuting Zhang, Weilin Pu, Jing Liu, Xiangguang Shi, Yanyun Ma, Chunya Ni, Yue Zhang, Yifei Zhu, Haiyang Li, Jing Wang, Jun Lin, Wenyu Wu
    TLDR Targeting specific genes in certain pathways may help treat male pattern baldness.
    This study analyzed gene expression differences in hair follicles from 10 male patients with androgenetic alopecia (AGA), identifying 506 mRNAs, 55 microRNAs, and 127 long noncoding RNAs differentially expressed in balding areas. Key pathways involved are the hypoxia-inducible factor (HIF)-1 and Wnt/β-catenin signaling pathways. Downregulation of HIF-1 pathway genes (EGLN1, EGLN3) and Wnt pathway inhibitors (SERPINF1, SFRP2) was found to stimulate dermal papilla cell proliferation and hair growth, suggesting these genes as potential therapeutic targets for AGA. The study underscores the need for further research with larger sample sizes to confirm these findings.
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