Insights into Male Androgenetic Alopecia: Differential Gene Expression Profiling of Plucked Hair Follicles and Integration with Genetic Data

July 2018 in “ Journal of Investigative Dermatology ”

Lara M. Hochfeld, Andreas Keller, Thomas Anhalt, Nadine Fricker, Markus M. Nöthen, Stefanie Heilmann-Heimbach

androgenetic alopecia AGA microRNAs mRNAs ceramide biosynthesis GADD45 signaling androgen receptor WNT3 RORA EPHB1 male pattern baldness ceramide

Studysummary This article reviews the genetic research on male androgenetic alopecia, highlighting that over 300 associated risk variants have been identified, with unclear mechanisms of action.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

This study aimed to identify genes and pathways relevant to male androgenetic alopecia (AGA) by comparing gene expression profiles between hair follicles that are prone to AGA and those that are not. The study found differentially expressed microRNAs and mRNAs between frontal and occipital hair follicles, and identified pathways that are potentially relevant to AGA, such as "ceramide biosynthesis" and "GADD45 signaling." The study also identified candidate genes, such as the androgen receptor, WNT3, and RORA, that may contribute to AGA. Integration of gene expression data with genetic association data led to the identification of seven genomic regions, including the gene EPHB1, that may be involved in AGA pathogenesis.

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