The Hair Loss Encyclopedia

Genomewide Differential Expression Profiling of Long Non-Coding RNAs in Androgenetic Alopecia in a Chinese Male Population

August 2017 in “ Journal of The European Academy of Dermatology and Venereology ”

Linlin Bao, Aijiao Yu, Yao-Jia Luo, Tian Tian, Yuxi C. Dong, Haifeng Zong, Hong-Duo Chen, Xing-Hua Gao, Xue-Gang Xu, Yuan-Hong Li

androgenetic alopecia long non-coding RNAs lncRNAs genomic analysis real-time qRT-PCR functional pathway analysis AGA qRT-PCR

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TLDR Found different long non-coding RNAs in balding Chinese men, which may help create new treatments.

This study aimed to identify differentially expressed long non-coding RNAs (lncRNAs) in androgenetic alopecia (AGA) in a Chinese male population. The researchers used genomic analysis to compare AGA tissues with adjacent normal tissues and identified several lncRNAs that were differentially expressed. They also conducted functional pathway analysis and confirmed the expression of selected lncRNAs using real-time qRT-PCR. The study provides insights into the molecular mechanisms underlying AGA and may contribute to the development of new therapeutic strategies.

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9 / 9 results

research Comparative Transcriptome Profiling Provides New Insights Into Mechanisms of Androgenetic Alopecia Progression

12 citations , January 2017 in “British Journal of Dermatology”

AGA progression involves increased lipid synthesis, electron transport, and hair follicle miniaturization.

research Frontal Fibrosing Alopecia: Reflections and Hypotheses on Etiology and Pathogenesis

68 citations , October 2016 in “Experimental dermatology”

FFA's causes may include environmental triggers and genetic factors.

research Androgenetic Alopecia: Modeling Progression and Regrowth

4 citations , June 2016 in “Experimental Dermatology”

AGA causes hair loss through follicle miniaturization and hair cycle changes; regrowth depends on anagen initiation in kenogen follicles.

research Androgenetic Alopecia: New Insights Into the Pathogenesis and Mechanism of Hair Loss

33 citations , August 2015 in “F1000Research”

New model shows muscle affects hair loss differently in men and women.

research Investigation of Six Novel Susceptibility Loci for Male Androgenetic Alopecia in Women With Female Pattern Hair Loss

25 citations , November 2013 in “Journal of Dermatological Science”

Six new hair loss factors in men not linked to female hair loss.

research Molecular Basis of Androgenetic Alopecia: From Androgen to Paracrine Mediators Through Dermal Papilla

122 citations , January 2011 in “Journal of Dermatological Science”

Male pattern baldness involves hormones and cell signals affecting hair growth.

research Peripheral Blood Gene Expression in Alopecia Areata Reveals Molecular Pathways Distinguishing Heritability, Disease, and Severity

20 citations , June 2010 in “Genes and Immunity”

Blood tests can help understand the genetic differences in people with alopecia areata, including how severe it is and if it's inherited.

research Prevalence and Types of Androgenetic Alopecia in Shanghai, China: A Community-Based Study

66 citations , March 2009 in “British Journal of Dermatology”

Chinese men have lower AGA rates than Caucasians, with type III vertex most common; family history is important.

research Conditional Disruption of Hedgehog Signaling Pathway Defines Its Critical Role in Hair Development and Regeneration

194 citations , May 2000 in “Journal of Investigative Dermatology”

The hedgehog signaling pathway is crucial for hair growth but not for the initial creation of hair follicles.